This challenge remains because of cross-reactivity among flaviviruses, especially in a context of secondary
flavivirus infection or previous immunization.
The non-structural proteins were involved in
flavivirus assembly (20).
"Other studies have used CRISPR genetic screens to identify cellular genes that are required for
flavivirus infection.
Routine diagnosis of
Flavivirus infections is usually made either through antibody detection by ELISA (enzyme-linked immunosorbent assay) or RT-PCR (reverse transcription polymerase chain reaction), depending on the phase of the disease.
Flavivirus. The Flaviviridae represent an extensive group of ssRNA viruses with a diverse nucleotide composition.
So far, two PRRs, toll-like receptors (TLRs) and retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) [18, 19], are identified to have a crucial function in resisting
flavivirus invasion.
Zika virus (ZIKV) is an arthropod-borne virus in the genus
Flavivirus, family Flaviviridae (1).
Flaviviruses are predominantly transmitted by a mosquito vector, but Zika virus is the first
Flavivirus to demonstrate sexual transmission.
In addition to the flaviviruses (genus
Flavivirus), the family includes 2 other genera, the hepaciviruses (genus Hepacivirus, which includes hepatitis C virus and GB virus B) and pestiviruses (genus Pestivirus, which includes bovine viral diarrhea virus and classical swine fever virus).
The Flaviviridae family,
Flavivirus genus, consists of a variety of viruses transmitted by blood-feeding arthropod species, several of which represent emergent or reemergent pathogens including Zika (ZIKV), Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), and West Nile (WNV) viruses.
Of those 56 patients, 34 (61%) were found to have evidence of either Zika or another related
flavivirus. Ten (18%) of those 56 were confirmed to have Zika virus, and 1 patient who received treatment for GBS died of septic shock.