Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption
in the West of Iran (2005-2014).
In the present study, fixed drug eruptions
were the commonest (21.
Fixed drug eruption
due to fixed dose combination: A novel case.
Patients 1 Fixed drug eruption
Antimalarial, Fluroquinolones 2 Acneform eruption 7 Systemic Steroids 3 SJ syndrome 6 Isoniazid, phenytoin, Carbamazepine, Septran 4 Melasma 5 Oral contraceptive pills 5 Angioedema 4 Penicillin, Salicylates 6 Erythema 4 Sulfonamides multiformae 7 Urticaria 3 NSAIDs,ACE inhibitors 8 Drug induced 3 Chloroquine Erythroderma 9 Maculopapular 3 Ampicillin, Chloroquine exanthema 10 Pellagrous 3 Isoniazid dermatitis 11 Hypertrichosis 2 Systemic Steroid 12 Stria 2 Systemic Steroid 13 Hyperpigmentation 1 Clofazamine 14 Bullous FDR 1 Metronidazole 15 Phototoxic reaction 1 Hydroxychloroquine
Ninety eight fixed drug eruptions
with provocation tests.
They were also reassured of the relative safety of provocation tests in fixed drug eruption
Fixed drug eruption
(FDE ) was first described by Brocq in 1894 in association with antipyrine therapy.
51%) each of drug induced lichenoid reaction, fixed drug eruption
, follicular lichen planus, bullous lichen planus, lichen striatus, & lichenoid tattoo reaction.
Conclusion Frequency distribution of the offending drugs and the adverse reactions revealed that cephradine was responsible for maculopapular rash, sulphonamides for Stevens-Johnson syndrome, indigenous medicines for exfoliative dermatitis, NSAIDs for urticaria and paracetamol for fixed drug eruption
In our case, the clinical findings and the temporal association with the drug intake and the patient's history established Azithromycin to be the culprit in causing the Fixed Drug Eruption
2) Cutaneous lesions of fixed drug eruption
start as a solitary erythematous macule that subsequently evolves into an edematous plaque.
Other findings include tenderness/edema of hands and feet, hyperpigmented macules over the nose and cheeks, fixed drug eruptions
, erythema nodosum, erythema multiforme, generalized urticarial eruptions, and flare up of pre-existing psoriasis and lichen planus (7).
4%) were diagnosed with fixed drug eruptions
and 5 cases (4.
Pilar Tornero and colleagues used patch testing and control oral challenge in patients with previous fixed drug eruptions
to trimethoprim-sulfamethoxazole or an unknown sulfonamide (Contact Dermatitis 2004;51:57-62).
In kids with HIV, we do see fixed drug eruptions
in the same area of the body.