filaggrin


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the main protein of the keratohyalin granules

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References in periodicals archive ?
Caption: Deficits in filaggrin, lipids, etc, increase permeability, allowing penetration by allergens or microbes
To conclude, omalizumab appears to work quite well in pediatric patients, and also in adult patients without extremely elevated IgE levels, and especially in those with no filaggrin gene mutations.
Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype.
Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice.
Makinson et al., "Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations," Journal of Allergy and Clinical Immunology, vol.
The infants were also screened for a mutation in the filaggrin gene.
Common loss-offunction variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic eczema.
"This increase in sensitivity is associated with a genetic predisposition to a skin barrier defect brought about by mutations in the gene encoding filaggrin.
Expression of cornification-related molecules including involucrin, filaggrin, caspase 14 and calcium-sensing receptor was higher in the AH
Because filaggrin mutations are associated with hyperlinear palms and a tendency toward skin dryness, hyperlinearity suggests a diagnosis of AD.
The four citrullinated proteins, filaggrin, fibrinogen, vimentin, and collagen type II, have been described as the major autoantigens in RA [5-7].
Specifically, disordered deimination of the joint proteins, filaggrin [21] and vimentin [22], generates antigenic epitopes [23] which can trigger a sustained autoimmune attack that eventually destroys the synovial compartment [24].
In particular, filaggrin (FLG) is an important protein in the skin and plays an important role in maintaining the integrity of the skin barrier [28].
Reducing inflammation, promoting inherent defense barriers, and immune functions by upregulating the expression of essential homeostatic protein and filaggrin in human tissue.