This case-control study identified that members of the case group were twice as likely to have family members with CKD undergoing RRT than members of the control group, showing familial aggregation
and familial predisposition to renal lesion in this representative sample of individuals with end-stage CKD associated with hypertension or type 2 diabetes mellitus.
Previous studies among Moroccans and Tunisians indicated familial aggregation
of T2D, but the figures were much lower than those observed among the Omani population.
Though obesity shows a familial aggregation
, central obesity typified by high waist to hip ratio (WHR) is found to be a risk factor for diabetes.
Previous studies have documented a similar familial aggregation
of IL-10 production from peripheral blood cells in SLE families, and in this study the familial correlation of IL-10 also extended to spouses of SLE patients .
First, it is now clear that pancreatic cancer aggregates in some families, and some of the genes responsible for the familial aggregation
of pancreatic cancer have been discovered.
Both genetic inheritance and sharing of common environment in the same family explain the increased risk of PD of relatives of PD cases compared with relatives of controls in familial aggregation
"While IBS aggregates in fatuities, it is conceivable that such aggregation may be explained by familial aggregation
of somatization," they suggested.
The data that have been collected to support the role of genetics in ARM have relied on twin, familial aggregation
, and segregation analysis studies.
of reading and spelling disabilities has been observed repeatedly since the first description of "word blindness" in the late 1890s (e.g., Gilger, Borecki, DeFries, & Pennington, 1994; Hinshelwood, 1907; Raskind, Hsu, Berninger, Thomson, & Wijsman, 2001; Schulte-Korne, Deimel, Muller, Gutenbrunner, & Remschmidt, 1996; Tallal, Ross, & Curtiss, 1989; Vogler, DeFries, & Decker, 1985; Wolff & Melngailis, 1994).
It can be seen that for IQ, HITS, MAE and SD the MZ correlations are higher than their DZ counterparts indicating additive genetic control of familial aggregation
for psychometric IQ and coincidence timing.
Evidence supporting the validity of ADHD includes the long-term developmental course..., cross-national studies revealing similar risk factors, familial aggregation
Commonly, familial aggregation
of a complex trait usually does not follow a clear pattern of segregation.
Studies have suggested that genetic components may play a role in NPC development.[sup] For example, familial aggregation
of NPC has been widely observed in both low and high incidence populations.[sup] Furthermore, Asian and African immigrants to western countries have a higher incidence of NPC, compared with local populations.[sup] However, research has also shown that environmental factors play a role in the development of the disease.
(14.) Zachara E, Caforio AL, Carboni GP, et al Familial aggregation
of idiopathic dilated cardiomyopathy: clinical features and pedigree analysis in 14 families.
"Case reports have suggested familial aggregation
[the occurrence of more cases of a given disorder in close relatives of a person with the disorder than in control families], but to what extent this is caused by common environment or inheritance is unknown," he added.