Bempedoic acid and the bempedoic acid / ezetimibe
combination tablet are targeted therapies that are being developed to significantly lower elevated LDL-C levels in patients with hypercholesterolemia, including patients inadequately treated with current lipid-modifying therapies.
(Zetia) can be used initially and if LDL-C remains above 70 mg/dL, then consideration can be given to the addition of a PCSK9-inhibitor therapy (strength of recommendation: ezetimibe
When combined in a single pill with ezetimibe
, which lowers LDL by stimulating the LDL receptor, the lipid-lowering impact is magnified over that of either drug alone.
For patients with very high cholesterol levels, adding a PCSK9 inhibitor (Repatha[R], Praluent[R]) instead of ezetimibe
can cause their cholesterol to drop an additional 50 percent.
Reducing dietary sterol intake together with ezetimibe
(10 mg daily) lowered the LDL-C concentration by 71% to 3.8 mmol/L.
We performed a retrospective analysis on data from 1297 patients with FH from 6 clinics across Canada (Coauthor involved: RAH; LB; JB, PC; RD, AB, JG, IR; DG, DB) in whom a baseline LDL-C was available before the initiation of statins or ezetimibe
and in whom an LDL-C was available within 18 months after the initiation of therapy [mean 7.2 (3.8) months].
Most of the time, you can get there using a statin and ezetimibe
The mice treated with ezetimibe
(10 mg/kg), ECHE (100 and 500 mg/kg), and D-mannitol (10 mg/kg) significantly showed a reduction in the concentration of both total cholesterol and non-HDL cholesterol compared to the group that developed hypercholesterolemia.
Plasma cholesterol (chol) and in particular LDL-chol can be lowered with drug treatments reducing chol absorption (ezetimibe
, EZE), chol synthesis (statins), or both.
Objective: To investigate the effect of ezetimibe
on platelet functions as a drug which increases mevalonate levels.
The class is divided into eight subclasses: bile acid sequestrants; fibric acid derivatives; HMG-CoA inhibitors; immunoglobulins; monoclonal antibodies; oligonucleotide inhibitors; and vitamins; as well as two miscellaneous drugs, ezetimibe
(Zetia) and lomitapide (Juxtapid).
A It sounds as if your doctor was referring to ezetimibe
(Zetia), which helps to lower cholesterol by reducing the amount of cholesterol that is absorbed through the digestive tract.
"While statins inhibit the production of cholesterol in the liver, ezetimibe
decreases the amount of cholesterol we absorb from the food we eat," Dr.
, a first-in-class drug that prevents cholesterol absorption in the small intestine, is used either in combination with statins or alone in statin-intolerant patients.