subitum, or roseola, classically presents in children aged 6 months-3 years.
Histological differential diagnoses include spongiotic dermatitis with secondary impetiginization, early guttate psoriasis, viral exanthem
, and acute spongiotic dermatitis in the fully developed stage and postinflammatory hyperpigmentation and chronic spongiotic dermatitis in the late stage .
The contagious period starts 1-2 days before the appearance of the exanthem
and lasts till all the vesicles have crusted, usually within 5-7 days7.
Mgone, "Measles: not just another viral exanthem
," The Lancet, vol.
In children, the major difficulty in the diagnosis of DR is differentiation of maculopapular drug eruptions from viral exanthem
which is observed very commonly in this age group.
Additional history of potential relevance is of a herpetiform exanthem
involving the penis in 1987, which resolved with no further issue following antiviral treatment.
Maculopapular rash (maculopapular exanthem
) is the most frequent (accounting for about 95%) clinical manifestation of non-immediate (type IV) hypersensitivity reactions, due to drugs (5).
Two other women in the placebo group reported clysenteria and an exanthem
at the trunk and upper extremities without the need of an emergency consultation.
More recently, however, genomic investigations have revealed that parvovirus B19 (the cause of the childhood exanthem
fifth disease), and human herpesvirus 6 (the cause of the childhood exanthem
roseola infantum) are the most commonly isolated organisms in cases of suspected viral myocarditis.
(5), (7) As the name implies, the rash resembles a viral exanthem
and this, as well as other inflammatory conditions with a similar presentation, should be excluded.
Measles: not just another viral exanthem
. Lancet 2003 Mar;361(9359):763-773.
Parvovirus B19 infection associated with acute hepatitis and a purpuric exanthem
. Br J Dermatol 1999;141:160-1.
Rare, prodromal pruritic popular rash possible.
Clinicians have learned to keep an eye out for the bad actors, like oral mucosa necrosis that could signal Stevens-Johnson syndrome, or the centripetal spread of exanthem
with petechiae from a tick bite that could signal Rocky Mountain spotted fever, he said at a women's and pediatric dermatology seminar sponsored by Skin Disease Education Foundation (SDEF).