Several anticonvulsants are found among the drugs implicated as a cause of DILE, such as CBZ, phenytoin, ethosuximide
, trimethadione, primidone, valproic acid, and zonisamide.
In contrast, ethosuximide
suppressed 60% of seizure activity at exposures associated with the optimal human dose.
Avoid these enzyme-inducing Consider these non-enzyme-inducing antiepileptic drugs antiepileptic drugs * Carbamazepine (Tegretol) * Ethosuximide
(Zarontin) * Felbamate (Felbatol) * Gabapentin (Neurontin) * Lamotrigine (Lamictal) * Levetiracetam (Keppra) * Oxcarbazepine (Trileptal) * Pregabalin (Lyrica) * Phenobarbital (Luminal) * Tiagabine (Gabitril) * Phenytoin (Dilantin) * Valproate (Depakote) * Primidone (Mysoline) * Vigabatrin (Sabril) * Topiramate (Topamax) * Zonisamide (Zonegran) * Benzodiazepines OCs, oral contraceptives.
The roles of long-term EEG monitoring and ethosuximide
. Acta Paediatr Scand, 74, 409-415.
, indicated specifically for absence seizures, again was hardly used in these patients, probably because absence seizure was not diagnosed in any of the patients.
Evaluation of gabapentin and ethosuximide
for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.
Phenytoin, benzodiazepines, carbamazepine, Valproic acid ethosuximide
16 Which anti-cancer drugs need TDM?
Average Antiepileptic spike drugs (c) frequency (b) 1 17 Lamotrigine, topiramate, clonazepam 2 33 Levetiracetam, ethosuximide
, methosuximide 3 38 Gabapentin, divalproex sodium 4 46 Levetiracetam, oxcarbazepine, zonisamide 5 0 Topiramate, lamotrigine 6 100 Levetiracetam, lamotrigine, clonazepam 7 14 Oxcarbazepine, gabapentin 8 0 Levetiracetam, divalproex sodium 9 5 Levetiracetam 10 0 Lamotrigine, levetiracetam M [+ or -] SD 25.3 [+ or -] 31.2 Min 0 Max 100 Nr.
and valproate are the only antiepileptic drugs with proven efficacy.
The acute effects of systemic (ip) injections of ethosuximide
(ETX), diazepam (DZP) and carbamazepine (CBZ) were examined in 20 F9 FMUSP-rats.
Pharmacotherapy of epilepsy includes phenytoin, carbamazepine, valproate, ethosuximide
, phenobarbital, benzodiazepines, vigabatrin, and gabapentin; however their use is restricted based on certain severe adverse effects such as hypersensitivity, sedation, megaloblastic anaemia, and teratogenic effect .
Kim, "Induction of neuronal differentiation of rat muscle-derived stem cells in vitro using basic fibroblast growth factor and ethosuximide
," International Journal of Molecular Sciences, vol.
Larsson et al., "Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide
," Journal of Controlled Release, vol.
Therefore, although some nonselective T-type blockers such as ethosuximide
or mibefradil can reverse both tactile hypersensitivity and thermal hyperalgesia in various pain models [260, 261], development of subtype-specific antagonists of T-type channels is desirable.