estrogen antagonist


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Synonyms for estrogen antagonist

an antagonist for estrogen that is used in the treatment of breast cancer

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References in periodicals archive ?
Simultaneously, raloxifene acts as an estrogen antagonist at hormone-sensitive breast cancer tissue.
Basis for weekly dosing schedule of Ormeloxifene are the long elimination half-life and a long lasting estrogen antagonist action.
Bisphenol AF is a potent estrogen agonist for ER[alpha] and a potent estrogen antagonist for ER[beta].
Tea also contains phytoestrogens and can have an estrogen antagonist effect on endometrial cells.
griffoniana could be completely suppressed by the pure estrogen antagonist, ICI 182,780, suggesting that the compounds exert their activities through ER[alpha].
As with its pharmacologic relatives tamoxifen and raloxifene, ospemifene acts as an estrogen agonist in some tissues and an estrogen antagonist in others.
The estrogen antagonist ICI 164384, for example, attenuates the effects of cadmium on gene expression.
Tamoxifen, regarded as an estrogen antagonist in the adult breast but an agonist during development and in the adult liver, also acted in an estrogenic manner in the developing mammary gland.
The objectives of the first phase of the OECD validation work were to a) demonstrate, in immature and adult OVX rats, the dose-response relationship between uterine weight and a reference estrogen using two possible routes of administration--oral gavage and subcutaneous injection; b) investigate intra- and interlaboratory variation and identify any appropriate protocol refinements; c) compare the performance of the protocols; and d) demonstrate the feasibility of the protocols to identify potential antiestrogenic activity using a pure estrogen antagonist.
These are agents that--unlike distinct estrogen agonists or estrogen antagonists, which either boost or block estrogen--selectively enhance estrogenic activity in some tissue while inhibiting estrogenic activity in other tissue.
FCE activated the expression of estrogen responsive reporter genes in MCF-7 cell lines while estrogen antagonists like tamoxifen downregulated the effects.