Of fetal hypoxic lesions, mild erythroblastosis of fetal blood (Figure 6, A) is regarded as the only reliable (and, therefore, the best) evidence of chronic, in utero hypoxia; however, fetal erythroblasts
can also be released from their stores in response to acute hypoxia.
iron metabolism in sideroblastic and sideropenic states.
quintana is located in erythrocytes during asymptomatic bacteremia (13) and has been observed in erythroblasts
in bone marrow in bacteremic patients (14).
The chromatin of differentiating erythroblasts
is cleaved into large size fragments independent of caspase activated DNase and apoptosis inducing factor.
Anaemia is promoted by erythropoietin deficiency, shortened existence of red blood cells, death of immature erythroblasts
due to the Fas ligand and TRAIL, decreased responsiveness of the erythron to proliferative signals of erythropoietin, and the myelosuppressive effect of the chemotherapy (32), (33).
13) Transferrin receptors on erythroblasts
bind the iron-transferrin complexes, which then undergo endocytosis.
Previous studies, all done in the laboratory, had suggested that macrophages in the bone marrow act as nurse cells for erythroblasts
, which are RBC precursors.
More specifically, they found, the process of stem cell differentiation stalled at the stage where mitochondria were degraded in erythroblasts
, the precursors of erythrocytes.
Indeed, an in vitro study by Leberbauer and colleagues (11) has shown that androgen enhances proliferation of female, but not male, human erythroblasts
Continuous stimulation with EPO triggers the differentiation of colony-forming unit-erythroid cells into erythroblasts
, which lose their nuclei to form reticulocytes.
In [beta]-thalassemia, tetramers of [alpha] globin are unstable in erythrocytes and bone-marrow erythroblasts
, resulting in hemolytic anemia and intramedullary ceil death.
9] /1, left shift in the differential blood count with 8% myeloblasts and 4% erythroblasts
A recent review of canine bone marrow disorders characterized CML as having total leukocyte counts >100 000 cells/[micro]l with mostly band and segmented neutrophils, occasional atypical blast cells, hypercellular bone marrow, and increased numbers of granulocytes to erythroblasts
This erythropoietin apparently acts on the bone marrow by stimulating the conversion of primitive undifferentiated cells to erythroblasts
These studies found abnormalities in developing erythroblasts
and evidence of increased phagocytosis of erythroblasts
at various stages of degradation.