'Vitamin D', diabetes', 'glycaemic control' and related terms were used in the search, along with Vitamin D-related terms including 'vitamin D' or 'vitamin D3' or 'cholecalciferol' or vitamin D2' or 'ergocalciferol
', and diabetes-related terms including diabetes' or 'type 2 diabetes' or 'T2DM' or hyperglycaemia' or hyperglycaemia'.
mostly originates from plant sources.
This does not even consider that some vitamin D assays do not adequately detect ergocalciferol
, the most commonly prescribed form of high-dose vitamin D in the US.
Vegetable sources provide ergocalciferol
(D2), and animal sources provide cholecalciferol (D3).
That said, intervention studies investigating bone status longitudinally have used inadequate ergocalciferol
(D2)/cholecalciferol (D3) doses of less than 3000 IU/day , while at present, there is consensus that oral doses of 50,000 IU D3 weekly for at least eight weeks are likely needed to significantly increase 25OHD levels above 75 nmol/l in vitamin D-deficient CF patients [8, 23, 32].
Vial 1 (*) Ingredient Amount per Unit Dose Fat Soluble Vitamins (**) Vitamin A 1 mg (retinol) (=3300 USP units) Vitamin D 5 mcg (ergocalciferol
) (=200 USP units) Vitamin E (dl-alpha-tocopheryl 10 mg acetate) (=10 USP units) Water Soluble Vitamins Vitamin C (ascorbic acid) 200 mg Niacinamide 40 mg Vitamin B2 (as riboflavin 3.6 mg 5-phosphate sodium) Vitamin B1 (thiamine) 6 mg Vitamin B6 (pyridoxine HC1) 6 mg Dexpanthenol 15 mg (d-pantothenyl alcohol) (*) WITH 30% PROPYLENE GLYCOL AND 2% GENTISIC ACID ETHANOLAMIDE AS STABILIZERS AND PRESERVATIVES; SODIUM HYDROXIDE FOR PH ADJUSTMENT; 1.6% POLYSORBATE 80; 0.028% POLYSORBATE 20; 0.002% BUTYLATED HYDROXYTOLU-ENE; 0.0005% BUTYLATED HYDROXYANI-SOLE.
"Vitamin D2 (ergocalciferol
) is found in mushrooms.
Cholecalciferol (Vitamin D3) and ergocalciferol
(Vitamin D2) are the primary sources of Vitamin D in vivo .
Diet is a minor source available in the form of ergocalciferol
from plant sources and cholecalciferol from animal sources although both forms are biologically equivalent.
"There are two kinds of supplements - D2 (ergocalciferol
), which is the type found in food, and D3 (cholecalciferol), which is the type made from sunlight.
The vitamin D content of food is composed of the parent vitamin D, cholecalciferol (vitD3) and ergocalciferol
(vitD2), and the metabolites, 25-hydroxyvitamin D3 (25OHD3) and 25-hydroxyvitamin D2 (250HD2).
The two main choices for vitamin D supplementation are vitamin D2 (ergocalciferol
) and vitamin D3 (cholecalciferol), and the therapeutic regimen of supplementation depends on several factors, such as the dosing regimen, severity of vitamin D deficiency, convenience for the dosing regimen, and safety [36, 37].
It is recommended that vitamin D (ergocalciferol
or cholecalciferol) should be administered in a dose of 50,000 IU per week for 8 weeks in addition to bimonthly supplements to maintain adequate vitamin D levels .
5-GMP-Na and ergocalciferol
(as vitamin [D.sub.2]) were purchased from Sigma-Aldrich (MO, USA).
A capsule of 50,000 IU of vitamin [D.sub.2] (ergocalciferol
) was administered once a week for six months.