To establish an HNA episome
, processive HNA-directed HNA polymerases as well as accessory proteins to support episome
maintenance and replication are required.
The molecular basis for this persistence is largely unknown, but 2 recent studies have given evidence in support of persistent circular HBoV episomes
In Burkitt's lymphoma, EBV is typically found in a latent form in the B cells, with its episome
expressing a pattern of gene transcripts which are composed of two small RNA molecules (the EBV encoded RNAs--EBERs) and the EB nuclear antigen 1 (EBNA1), so-called type I latency.
Whenever an infected cell divides, the episome
makes a copy of itself, and each daughter cell receives one.
Not integrated into our genome, It will roam, that episome
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Latency is characterized by maintenance of the viral genome as a nonintegrated episome
and expression of a limited number of viral genes and microRNAs.