This is already very valuable information for the enzymologist
. The simulations show that for transient state experiments where [(ES).sub.1] and [(ES).sub.2] states are well separated in time, small crystals must be used.
He intends the material to be useful for practicing enzymologists
involved in early stage drug discovery.
For graduate students, researchers, and scholars, Grosjean (structural enzymology and biochemistry, Universite Paris-Sud and Institut de Genetique et de Microbiologie, Center of National Research, France) compiles 41 chapters by geneticists, structural enzymologists
, and molecular biologists from Europe, North America, and Japan who discuss aspects of DNA and RNA modification-editing processes and repair mechanisms.
In all these cases, as the basic science surrounding their mechanism of action and their basic chemistry is nearing completion, the toxins (now called "specific molecular probes") have already entered the research arsenals of membrane biologists and physiologists and of neuroscientists and enzymologists
. Ultimately, they--or clinical drugs designed on their chemistry--will enter the physician's stockpile of available drugs.
In addition, in the mid- to late 1970s, one of the best enzymologists
I have ever known, Dave Dietzler, joined our division, and it was hard to avoid his love of enzymology.