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Enkephalin Surges in Dorsal Neostriatum as a Signal to Eat.
Other studies have shown that 2 and 15 Hz EA can increase the release of endomorphin, enkephalin, and [beta]-endorphin peptides, which involve the mu and delta receptors in the CNS[13, 22].
This increase in enkephalin, together with previous work done by this research group which showed that an opioid receptor blocker was less effective at reducing fat and sugar intake in the pups of the junk-food fed mothers, provides evidence for the first time that the opioid signalling pathway is less sensitive in junk-food exposed offspring.
"It seems likely that our enkephalin findings in rats mean that this neurotransmitter may drive some forms of overconsumption and addiction in people."
A natural brain chemical called enkephalin surged as rats began to eat M&M chocolate sweets.
Among the neurotransmitters that affect the release of gonadal secretions are endogenous opioid peptides like enkephalin, dynorphin, beta endorphins etc.
Enkephalinergic neurons are in contact with cerebral cortex and hypothalamus and the signal transmission at these sites is performed by enkephalin. Hypothalamic neurons secrete endorphin to the synaptic cleft.
Diamyd Medical (STO:DIAMB) (Pink Sheets:DMYDY) on Tuesday announced that its Phase II study, in which cancer pain is treated with the drug candidate NP2 Enkephalin, has recruited its last participant.
Here, it triggers cells to release the natural painkiller, enkephalin, to alleviate pain for four to six weeks.
Diamyd Medical's most advanced project in the NTDDS portfolio is NP2 Enkephalin against cancer pain.
Fink and his colleagues demonstrated that an HSV vector that produces the opioid peptide enkephalin reduces pain-related behavior in animal models of inflammatory pain, neuropathic pain, and pain caused by cancer (Pain Medicine 2009;10:1325-30).
* higher levels of enkephalin in the hypothalamus (due to a lower release of serotonin)
if the putamen is stained immunocytochemically with enkephalin one can observe that this compound will be concentrated in the areas where the striosomes are, which is around the striosomes periphery .
In animal studies, the HSV vector containing the preproenkephalin gene produced enkephalin, which provided a continuous analgesic effect.
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