The reason why the beetle produces an enantiomeric
mixture was unclear at the time of its discovery.
Their synthesis, which appeared in the Journal of the American Chemical Society (2003, 125, 9308), employs a tandem Diels-Alder/allylboration strategy which installs both stereocentres and the heterocyclic ring rapidly and with high levels of enantiomeric
The blackcurrant oil yields from different materials and changes in the concentrations of aroma compounds during the ripening process were studied, and the enantiomeric
ratio of some monoterpenoic compounds was determined.
For example, bacteria act as enzyme reactors to crank out huge quantities of one enantiomeric
form of vitamin C, and enzymes isolated from other microbes help produce the desired enantiomer of aspartame, an artificial sweetener.
For example, the quantitative determination of aromatic hydrocarbons in diesel fuels, the analysis of multicomponent mixtures containing sulfonylurea and carbamate pesticides, and the rapid separation of enantiomeric
pharmaceutical isomers (box) have all been successfully achieved with this clever analytical tool.
and Stable Isotope Analysis (Nguyen Thi Thao)
Pan, Synthesis and application of dehydroabietylisothiocyante as a new chiral derivatizing agent for the enantiomeric
separation of chiral compounds by capillary, Anal.
It was concluded therefore, that PLB could not attack the sn-2 ester linkage of unnatural enantiomeric
PC but attacked the sn-3 ester linkage non-stereospecifically.
Chapter 7 discussed importance of enantiomeric
purity for biological activity through illustration of several alkaloid examples.
Finally, we determined diastereomeric and enantiomeric
patterns to improve current knowledge concerning isomer- and enantiomer-specific fate in the human body.
S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric
form of the soy isoflavone metabolite produced by human intestinal bacterial flora.
Currently, synthetic routes to synthesize the unnatural analogs of the [alpha]-amino acids easily, inexpensively, and with sufficient enantiomeric
yields does not exist.
Beetle pheromone chemistry is somewhat unusual as compared to other insects, in that enantiomeric
composition may play a critical role in defining the activity of the pheromone.
Topics covered include principles, instrumentation, reverse-phase, ion-exchange, ion-pair, ion, size-exclusion and affinity chromatography, as well as analytical methods, preparative HPLC and enantiomeric
Sorption and binding ability was studied along with the permeation selectivity of underivatized enantiomeric
solution of Phe using Ultrafiltration experiments.