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  • noun

Words related to dyscrasia

an abnormal or physiologically unbalanced state of the body

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Medical and dental history as well as assessment of haematological and coagulation disorders and absence of ecchymosis, epistaxis or gingival bleeding are helpful in distinguishing it from dental trauma and blood dyscrasias which include anaemia, thrombocytopenia, leukaemia and haemophilia.3,5 As it is a benign condition, management is usually directed at relieving the discomfort by prescribing NSAIDs and mouthwash containing chlorhexidine digluconate.
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder,that occurs in 3% of the population aged more than 50 years, and is the commonest among plasma cell dyscrasias.1,2 The hallmark of Monoclonal gammopathies is the expansion of a single clone of plasma cells, which yields a homogeneous monoclonal protein (M-protein/M-component or paraprotein).
Each affected employee had one or more demographic risk factors for plasma cell dyscrasias, including male sex (myeloma, MGUS, and WM), older age (all diagnoses), and black race (myeloma and MGUS).
It maybe preceded by monoclonal gammopathy of undetermined significance and may occur in association with other plasma cell dyscrasias, such as multiple myeloma and Waldenstrom macroglobulinemia.
Plasma cell neoplasms result from clonal expansion of plasma cells which produce large amount of M-protein, with plasma cell myeloma being the most common disorder of plasma cell dyscrasias [1].
CBC and Diff test showed WBC, RBC, Hb, and HCT were lower than normal range; however, this patient has consumed phenytoin and lamotrigine for about 13 years so these drugs can cause dyscrasias [36].
Primary extramedullary plasmacytoma is also rare, accounting for only around 4% of plasma cell dyscrasias. There is some data suggesting that the risk of progression to multiple myeloma from a solitary primary lymph node plasmacytoma is less than for other extramedullary plasmacytomata and that recurrence posttreatment is rare [6], but evidence is limited to small case series and individual case reports.
Data regarding other, co-morbidities like, hypertension, diabetes mellitus, hepatitis, gastrointestinal disorders, cardiac, renal disorders and blood dyscrasias was also collected.
Other diseases in which patients experience Raynaud's are dermatomyositis, rheumatoid arthritis, atherosclerosis and various blood dyscrasias. Raynaud's may also occur in individuals whose job requires them to use vibrating hand tools, such as a chain saw or a jackhammer, and also in patients who frequently play piano or keyboards.
(14,17) Leukocytosis can affect blood monitoring, possibly masking other blood dyscrasias, when lithium is used concurrently with clozapine.
Exclusion criteria consisted of pregnancy/planning pregnancy, lactating mothers, Liver disease (hepatitis B, C and chronic liver disease), chronic infections like tuberculosis etc., and previously diagnosed/ Immunodeficiency syndromes or blood dyscrasias, as per medical record.
(3) There is an absence of related organ or tissue impairment due to plasma cell dyscrasias, such as renal failure or anaemia, and normal calcium levels.
A few case reports have indicated that clozapine may be associated with blood dyscrasias other than leukocytosis and agranulocytosis, such as leukocytosis (3).
Renal cysts, blood dyscrasias, or anticoagulant and antiplatelet therapy are some of the less common causes.