As [o.sup.8]dG contained in htel GQ was found not to be a substrate of the glycosylase enzymes that repair [o.sup.8]dG in duplex DNA
, such as the hOOG1 and NEIL enzymes , [o.sup.8]G can become a persistent lesion in GQs.
Similarly, the thermal stability of duplex DNA
fragments containing the s-z pair was lower, as compared to those with the s-y pair.
It has been shown to bind tightly to duplex DNA
as a bisintercalator with a preference to the CpG sequence.
Interstrand cross-links generated by abasic sites in duplex DNA
. J Am Chem Soc 2007; 129:1852-3.
We have observed that the selective generation of radical intermediates in DNA architectures that act as models of substrates which form during the process of replication results in elevated levels of strand-break products when compared to duplex DNA
. The formation of 3' and 5'-overhangs (OvHgs) containing a phosphate at the ss-dsDNA junction, as well as duplex substrates containing a terminal phosphate was observed .
He then examines the structure, synthesis and function of RNA and the secondary structure of duplex DNA
, and the primary sequences of DNA.
The structure of duplex DNA
in the nucleosome core particle: an alternative model.
These processes include replication of single-stranded RNA viruses of bacteria, plants, and possibly mammals; replication of duplex DNA
plasmids of fungal mitochondria; replication of retroviral and pararetroviral genomes; and replication of modern chromosomal telomeres.
 studied G-loop formation in immunoglobulin class-switch regions and a telomeric repeat and have proposed that invasion of RNA into the duplex DNA
initiates the formation.
To explore more fully the specificity of detection, we performed competition assays: we made 2 duplex DNA
competitors, one containing a consensus NF-[kappa]B-binding site (GGGACTTTCC) as a specific competitor and the other not containing an NF-[kappa]B-binding site as the nonspecific competitor.
For the HAS technology, we developed two detection modalities based on differences in the physical and biochemical properties between Holliday junctions (HJs) and duplex DNA
or single-stranded DNA.
Predicting sequence-dependent melting stability of short duplex DNA