In a new study recently published in Frontiers in Neurology, James, Carlstedt and other collaborators set out to understand how the implanted sensory root was connecting with the spinal cord in the dorsal horn
Lamina specific suppression of dorsal horn
unit activity by ketamine hydrochloride.
These spikes transmit to lamina I secondary sensory neurons in dorsal horn
, and finally to sensory cortex evoking a pain sensation.
SNI induced a robust astrocytic activation, indicated by GFAP upregulation in the ipsilateral spinal dorsal horn
of SNI group (Fig.
The robust increase of JNK expression in JNK-IR cells was observed in the superficial region (laminae I–III) of the dorsal horn
Interneuronal networks in the dorsal horn
are responsible not only for the transmission of nociceptive information but also help modulate that information and pass it on to other spinal cord neurons, therefore, certain patterns of stimulation can lead to increase nociceptive transmission or inputs result in the inhibition of projection neurons.
They act by binding to presynaptic C-fibers and postsynaptic dorsal horn
As shown in figure 1, control rats showed a few c-Fos positive nuclei scattered throughout the dorsal horn
without any clustering or apparent pattern, 2 hours after they received intrathecal saline.
Nociceptor signals, following acute injury, undergo complex processing in the dorsal horn
of the spinal cord (as explained by Melzack and Wall's gate control theory (12)).
In that study, whole-cell patch clamp recordings were performed from dorsal horn
NK1 expressing neurons in an acute spinal cord slice preparation .
Correlation between spinal neuron counts and axial muscle histologic changes in 15 SBV-infected newborn calves, Belgium, January-March 2012 * Structure examined Control WBD/calf ID calves WBD-0 WBD-1 A B C D E F Axial muscles, histology Musculus semispinalis 0 NT 0 0 0 3 0 capitis, cas Musculus semispinalis 0 NT 1 0 0 2 0 capitis, ces Spinal cord Dorsal horn
Spinal cord stimulation attenuates augmented dorsal horn
release of excitatory amino acids in mononeuropathy via a GABAergic mechanism.
The response properties of the dorsal horn
and brain stem neurons change due to continuous nociceptive input (12), altering the normal processing of nociceptive and non-nociceptive information.
Next, transmission occurs when action potential is transmitted to the dorsal horn
of the spinal cord (Pasero & McCaffery, 2011).
This analgesic effect is mediated by cannabinoid receptors within several nervous system areas: peri-aqueductal gray matter, medulla, thalamus, and the dorsal horn
of the spinal cord.