Another large study in 477 American adults found use of LPV/r, didanosine
, increasing viral load, and higher BMI to be associated with metabolic syndrome .
The purine analogues abacavir and didanosine
increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction J Antimicrob Chemother.
In their study, treatment with Zidovudine (ZVD) and Didanosine
(DDI) did not result in loss of hearing, even after taking into account noise exposure, immune status and age.
Zidovudine compared with didanosine
in patients with advanced HIV type 1 infection and little or no previous experience with zidovudine.
Once-daily combination therapy with emtricitabine, didanosine
, and efavirenz in human immunodeficiency virus-infected patients.
and stavudine became available for US$1 per day.
Among the NRTI drugs were biovir (ATC), composed by the combination of 300mg zidovudine (AZT) and 150mg lamivudine (3TC), 400 mg enteric didanosine
(DDI400), 300mg tenofovir (TDF) and 150mg lamivudine (3TC).
"I'hree nucleosides that have this effect are Retrovir (zidovudine), which is part of Combivir; Videx (didanosine
); and Zerit (stavudine).
Other licenses issued before the recent case of Nexavar include: Malaysian government issued a compulsory license to Indian companies to import generic variants of didanosine
(ddl), zidovudine (AZT) and lamivudine+zidovidine (Combivir).
In one such study  conducted at a pediatric and prenatal HIV clinic in a tertiary general hospital in Mumbai, India, on HIV-positive children in the age group of 5 months-14 years were started on HAART, of which 16% developed hepatotoxicity with elevated liver enzyme levels at least five times the baselines values, 12% had raised serum amylase without symptomatic pancreatitis, 12% had Zidovudine induced anemia, 9% had Nevirapine induced rash, 2% had Didanosine
induced pain in abdomen, 2% had Stavudine induced angioedema, and 2% had hepatic steatosis.
The most recognised form is distal sensory or axonal neuropathy, which is directly related to HIV-1 infection and often compounded by antiretroviral therapy, particularly the NRTIs, didanosine
(ddI) and d4T.
Among the some 200 new or revised monographs are ones on buspirone, linezolid, didanosine
, ribavirin, dronedarone, protease inhibitors, and oxycodone and rifamcyins.
The immunity-from-suit agreement signed with Matrix Laboratories Limited, a Mylan Company, enables the generic company to manufacture and sell atazanavir, as well as stavudine and didanosine
, in sub-Saharan Africa and India.
From the two-drug regimens of zidovudine and didanosine
to, for example, a combination of didanosine
every 6 hours (dissolved rather laboriously in purified water, and taken 2 hours away from any other drug) with indinavir taken three times daily (requiring an empty stomach so that patients had to set their alarm to ring during the night), plus stavudine.
FDA-Approved Antiretroviral Agents Nucleoside RTIs Nonnucleoside RTIs Protease inhibitors abacavir (ABC) delavirdine (DLV) atazanavir (ATV) didanosine
(ddl) efavirenz (EFZ) darunavir (DRV) emtricitabine (FTC) etravirine (ETV) fosamprenavir (Fos-APV) lamivudine (3TC) nevirapine (NVP) indinavir (IDV) stavudine (d4T) lopinavir/r (LPV/r) zidovudine (ZDV) nelfinavir (NFV) ritonavir (RTV) saquinavir (SQV) tipranavir (TPV) Nucleotide RTI Integrase inhibitor Fusion inhibitor tenofovir DF (TDF) raltegravir (RAL) enfuvirtide (T-20) CCR5 antagonist maraviroc (MVC) Notes: Six fixed-dose combinations are approved by the Food and Drug Administration.