Other recent studies show that within two years of starting lithium treatment, about 40 percent of manic depressives experience a new episode of mania, says William Z.
At the final follow-up, 12 of 35 manic depressives functioned well and generally lacked the psychiatric symptoms that had led to their hospitalization.
Individuals with mild mood swings or with manic depressive
relatives tend to express their creative potential in different ways, explain the researchers in the August JOURNAL OF ABNORMAL PSYCHOLOGY.
Four years after discharge, the lithium-treated manic patients--most of whom were later found to be manic depressives -- were doing significantly worse than the depressed subjects, who took other medications.
Nearly half of all patients on lithiumtake it improperly or stop using it against medical advice, factors that may account for the poor outcomes of some manic depressives, says NIMH scientific director Frederick K.
Most winter depressives
examined atNIMH ride a seasonal pendulum, becoming agitated, gregarious and impulsive in the spring and summer (SN: 3/8/86, p.
While this personality pattern applies to manic depressives in general, those patients who shifted from an excitable to a melancholic state, or vice versa, within the first eight weeks of the study had the worst prospects for recovery.
Over four years, there were 45 suicides among manic depressives and pure depressives in the sample.