Martin Jr., "Deoxyadenosine
metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease," Cell, vol.
Kool, "Structure and base pairing properties of a replicable nonpolar isostere for deoxyadenosine
," The Journal ofOrganic Chemistry, vol.
ADA is involved in this pathway and converts adenosine and deoxyadenosine
into inosine and deoxyinosine.
In pyrosequencing, the natural deoxyadenosine
triphosphate (dATP) results in false signals because, like ribose adenosine 5'-triphosphate (rATP), it is a substrate for luciferase.
Adenosine deaminase (ADA), an enzyme of purine salvage and catabolic pathway deaminates adenosine and deoxyadenosine
to form inosine and deoxy inosine respectively.
ADA has a role in purine metabolism that converts adenosine and deoxyadenosine
to inosine and deoxyinosine by irreversible deamination (20).
ABBREVIATIONS: bDNA = Branched DNA; DNA = Deoxyribonucleic Acid; dNTP = Deoxyribonucleotides; dATP = Deoxyadenosine
Triphosphate; dCTP = Deoxycytidine Triphosphate; dGTP = Deoxyguanosine Triphosphate; dTTP = Deoxythymidine Triphosphate; FDA = Food and Drug Administration; FRET = Fluorescence Resonance Energy Transfer; MRSA = Methicillin Resistant Staph aureus; MTB = Mycobacterium tuberculosis; NASBA = Nucleic Acid Sequence Based Amplification; PCR = Polymerase Chain Reaction; PFGE = Pulsed-Field Gel Electrophoresis; RT-PCR = Reverse Transcription Polymerase Chain Reaction; Taq = Thermus aquaticus; TMA = Transcription-Mediated Amplification; VRE = Vancomycin Resistant Enterococcus.
Adenosine deaminase (ADA) is an enzyme in the purine salvage pathway that catalyses the conversion of adenosine and deoxyadenosine
to inosine and deoxyinosine with the release of ammonia.
The commonly used cloning strategy utilizes the feature of Taq DNA polymerase to add a 3' overhanging deoxyadenosine
residues in most of the PCR products (1).
Nucleotide differences in the glycoprotein coding/noncoding region of Australian bat lyssavirus (ABLV) Nucleotide (a) Isolate host 4701 4751 4899 4987 5037 5058 Pteropus alecto (b) A G G C G A Pteropus poliocephalus (c) A G G C G A Pteropus alecto (d) C A A T A G Pteropus alecto (d) C A G T A G Pteropus scapulatus (d) C A G T A G Human (d) C A G T A G Pteropus alecto (e) C A G T A G (a) Nucleotide position from the Ballina isolate of the pteropid strain of ABLV (8); A, deoxyadenosine
; C, deoxcytidine; G, deoxyguanosine; T, thymidine.
This enzyme normally converts a molecule called deoxyadenosine
into another molecule called inosine.
The adduct of GSCH2OAc and deoxyadenosine
was identified as S-[l-(N7-deoxyadenosinyl)methyl]GSH.
This defect causes toxic levels of adenosine and deoxyadenosine
to accumulate in the blood, killing the germ-fighting B and T cells (lymphocytes).
The oligonucleotides were labeled by random hexamer priming (Feinberg and Vogelstein, 1983) with [.sup.32] P radioisotope of deoxyadenosine
5'-triphosphate and a commercial kit (Gibco/BRL, Grand Island, NY).