As we stated previously (Section 2), a total of 77 drawings from the monkey dentate nucleus were converted into digitized images using a scanner (Mustek 1200, Mustek System Inc., Taiwan) with a resolution of 600 dpi .
Finally, the posterolateral portions of cerebellar hemispheres are the neocerebellum (cerebro-cerebellum); axons originating from the dentate nucleus project to contralateral motor and pre-motor areas via the thalamus.
Dissection of the fixed brain should always be standardized and basic sampling for dementia evaluation should include blocks from the frontal, parietal, and temporal cortex; occipital cortex around the calcarine fissure; the hippocampus at the level of lateral geniculate body; the striatum; the mesencephalon at the level of the oculomotor nerve; the pons at the level of the locus coeruleus; the medulla oblongata at the level of the inferior olives; and the cerebellum and dentate nucleus. Spinal cord sampling should include at least 1 block from the cervical, thoracic, and lumbar segments.
Magnetic resonance imaging of the brain showed diffuse white matter lesions scattered in the subcortical and deep white matter over both cerebral hemispheres and periventricular region, most prominent in the left parietal lobe and frontoparietal regions, and subtle hyperintense lesions in bilateral dentate nucleus (Figure, panel A).
One such group of tracts, the dentothalamocortical pathways, brings information about oromotor function and speech production from the dentate nucleus. The dentate, located deep in the cerebellum, conveys information from the cerebellum to other structures.