Vanillin and 4-hydroxybenzyl alcohol promotes cell proliferation and neuroblast differentiation in the dentate gyrus
of mice via the increase of brain-derived neurotrophic factor and tropomyosin-related kinase B.
EXAMPLE 5, SAMPLE AUTOPSY SICNOUT: * Alzheimer disease neuropathologic changes, "high", A3B3C2: *** Thal phase for amyloid plaques: 5 (A3) *** Braak and Braak neurofibrillary stage: VI (B3) *** CERAD neuritic plaque score: Moderate (C2) *** Cerebral amyloid angiopathy, diffuse *** TDP-43 proteinopathy, with: ** Hippocampal sclerosis, bilateral, severe ** Frequent pathologic inclusions in hippocampus proper, dentate gyrus
, limbic regions, and basal forebrain * No Lewy body pathology is identified Comment: "High" AD neuropathologic change is identified, which per the 2012 NIA/AA guidelines is considered adequate explanation for clinical diagnosis of dementia in the appropriate context (Moline et al.
Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
Functional circuits of new neurons in the dentate gyrus
Ortiz-Lopez, "Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus
during aging of Balb/C mice," Experimental Gerontology, vol.
Gonadal hormone modulation of neurogenesis in the dentate gyrus
of adult male and female rodents.
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
The researchers have developed new analysis methods to evaluate neurotransmitter concentrations in the brains of normal and genetically modified mouse models for Alzheimer's disease (AD mice) and their study of AD mice shows that the high concentration of the GABA neurotransmitter in the reactive astrocytes of the dentate gyrus
correlates with the animals' poor performance on tests of learning and memory.
Neurosteroid PREGS protects neurite growth and survival of newborn neurons in the hippocampal dentate gyrus
of APPswe/PS1dE9 mice.
The layers of the dentate gyrus
showed only differences between the estrus and diestrus groups in the gcl and ml layers.
1A]ARs) increases the number of proliferating cells in the subgranular zone (SGZ) of the adult dentate gyrus
and enhances learning and memory in the mouse.
New neurons in the dentate gyrus
are involved in the expression of enhanced long-term memory following environmental enrichment.
An unexpected and key new observation from this study was a substantial and significant increase in cell count number in the dentate gyrus
region and specifically CA3 neuron population.
A defect in the dentate gyrus
of the hippocampus area is associated with cognitive decline, including impairments in learning and short-term memory, during aging (Patrylo & Williamson, 2007; Rosenzweig & Barnes, 2003).
Their brains also showed 58% less tau pathology in the dentate gyrus
of the hippocampus--an area important in memory.