Dendritic cell vaccines
provide another form of therapy for conditions that cannot be addressed with chemotherapy or radiation, such as metastatic renal cancer or malignant melanoma.
Under the new agreement, PCT will manufacture clinical supplies of ICT-140, a dendritic cell vaccine
targeting seven ovarian cancer antigens, using process improvements PCT will develop that can be applied to the manufacture of all ImmunoCellular's current vaccine product candidates, ICT-107, ICT-121 and ICT-140.
The vaccine, called sipuleucel-t (Provenge), is a dendritic cell vaccine
that treats advanced prostate cancer that no longer responds to hormone therapy.
Nierkens et al., "Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine
," Cancer Research, vol.
Potentiation of a dendritic cell vaccine
for murine renal cell carcinoma by CpG oligonucleotides.
Eight patients in the dendritic cell vaccine
study experienced remarkable long-term, progression-free survival after completing the vaccine therapy, even though they had widely metastatic disease and/or repeated appearance of new metastases despite various therapies.
The ovarian Phase II double-blind study will enroll approximately 99 patients who will be randomized in a 2:1 ratio to receive either autologous dendritic cell vaccine
or autologous monocytes as a comparator.
For example, the dendritic cell vaccine
, provenge (sipuleucel-T), targeting PAP for metastatic castration-resistant prostate cancer, was the first FDA-approved cell-based cancer vaccine in 2010 .
According to the new Services Agreement, Progenitor Cell Therapy will produce clinical supplies of ICT-140, a dendritic cell vaccine
targeting seven ovarian cancer antigens, using process improvements.
ICT-140 is a dendritic cell vaccine
targeting seven antigens that are over-expressed in ovarian cancer, as well as cancer stem cells.
A dendritic cell vaccine
personalized for each individual based on the patient's own tumor may increase median survival time in those with a deadly form of brain cancer called glioblastoma, an early-phase study at UCLA's Jonsson Comprehensive Cancer Center has found.