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The prognosis of the majority of these tumors is good, but is less favorable with cases with dedifferentiation. Long-term follow-up is indicated.
Treatment of breast adenocarcinoma metastasis to the neck: dedifferentiation of the tumor as suggested by hormone markers.
During malignant transformation where the cells undergo dedifferentiation, there is the return of embryonic pattern of expression that is enhanced expression of cytokeratin 8 and 18 is seen in OSCC and well as 80% of the tumour-associated mucosa.
Ovarian Mucinous Tumor with Malignant Mural Nodules: Dedifferentiation or Collision?
(23) In contrast, other studies have proposed that the dedifferentiation of mature cells triggers tumor development in the intestine.
Malta et al., "Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation," Cell, 2018; 173 (2): 338 DOI: 10.1016/j.cell.2018.03.034
It can be concluded that the increase in tumor dedifferentiation causes an increase in the amount of epithelium and stroma, and a decreased lumen of adenoid structures.
These cells lose their cellular features of terminal differentiation (dedifferentiation) and increase in fraction of tissue outgrowing normal cells alongside faulty tissue repair.
White matter/gray matter dedifferentiation has been described as a sign of ischemia and is associated with a poor neurological outcome in cardiac arrest.
Smith, "Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells," Nature Genetics, vol.
It has been generally accepted that ATC and PDTC usually develop from the dedifferentiation of differentiated thyroid cancer (DTC), which is supported by that histological concurrence of PDTC/ATC and DTC, and molecular inheritance from DTC to PDTC/ATC has been confirmed in various studies [11-16].
This phenomenon of greater and more diffuse cortical activity in the elderly was observed for both cognitive function and motor function, and it is still debated whether this so-called (cortical) overactivation is related to compensatory processes or dedifferentiation of (i.e., less distinctive) representations [21, 22].
Recurrence of thyroid cancer may be accompanied by dedifferentiation of the tumor which results in more aggressive behavior .
DDL generally shows high-grade sarcoma but can show low grade and a low ratio of dedifferentiation. Because the correlation of histological grade, ratio of dedifferentiation, and prognosis has been controversial, we should take care in making treatment decisions .
Hess et al., "Outcomes of patients with renal cell carcinoma and sarcomatoid dedifferentiation treated with nephrectomy and systemic therapies: comparison between the cytokine and targeted therapy eras," The Journal of Urology, vol.
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