"We herein report an exceptional case of extra-axial dedifferentiated
chordoma confirmed by the expression of brachyury, the first case report of this kind," reported surgical pathologist Dr.
The prognosis of paratesticular liposarcomas depends on the histological cell type, among well-differentiated, dedifferentiated
, pleomorphic and myxoid/round cell types.
The median survival times observed for well differentiated, dedifferentiated
, myxoid, and pleomorphic tumors were 104 (71.43, 136.57), 18 (0.52, 35.48), 65 (4.51, 125.50), and 29 (0.00, 74.09) months, respectively.
The remaining tumors were of high grade (2 dedifferentiated
carcinomas, 2 serous carcinomas, 1 clear cell carcinoma, and 4 mixed/other carcinomas, including malignant mixed Mullerian tumor).
It has been shown that progenitor or stem cells which are enriched with [CD133.sup.+] and OCT-4 have higher colony-forming capacity , in addition, the expression of OCT-4 in dedifferentiated
cells leads to cancer stem-like cell features with the acquired ability to form tumor spheroids, increased resistance to chemotherapeutic agents, and increased tumorigenic capacity .
We can only speculate whether the proliferating cells are actually derived from goblet or ciliated cells that have dedifferentiated
into a form of airway "progenitor" cell.
myoepithelial cells were shown to be capable of migration and cell division.
They are usually grouped in four main histologic types: myxoid/round cell, well differentiated, dedifferentiated
, and pleomorphic.
Liposarcoma varies in histologic patterns and can be classified into subtypes: well differentiated, myxoid, round cell type pleomorphic, and dedifferentiated
. Differential histologic diagnosis can be difficult and further analyses are required.
Cancer researchers speak of the latter as "dedifferentiated
For this product dedifferentiated
callus cells from a rare apple were cultivated.
(2) However, literature on dedifferentiated
tumors arising in LGEESS is sparse.
There were 941 (75.8%) well-differentiated liposarcomas and 300 (24.2%) dedifferentiated
Given that PDTC can arise from well differentiated carcinomas, during early stages the dedifferentiated
component could be assumed to initially appear encapsulated and noninvasive.
According to the WHO Classification of Tumors of Soft Tissue and Bone 2013, liposarcomas mainly have four histological subtypes: ALT/WDLS, dedifferentiated
liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma.