Neuroendocrine carcinoma (NEC) of the head and neck are thought to be derived from the APUD cell family (amine precursor uptake and decarboxylase
system), more specifically the Kulchitsky's cells.
Bien, "Antibodies to glutamic acid decarboxylase
define a form of limbic encephalitis," Annals of Neurology, vol.
Keywords: Limbic encephalitis, diabetes, anti-glutamic acid decarboxylase
Zarranz, "Experience with immunotherapy in 3 patients with cerebellar ataxia associated with anti-glutamic acid decarboxylase
antibodies," Neurologia, vol.
Although questioned repeatedly , current criteria for the diagnosis of LADA remain age at the onset, the presence of positive diabetes-associated autoantibodies--islet-cell cytoplasm autoantibodies (ICA), glutamic acid decarboxylase
autoantibodies (GAD65A), insulinoma-associated-2 antibodies--tyrosine phosphatase associated (IA-2A), zinc transporter 8 autoantibodies (ZnT8A); and satisfying glycemic control without insulin treatment for at least 6 months after diagnosis [5-8].
McMenamin et al., "Neuronal surface and glutamic acid decarboxylase
autoantibodies in nonparaneoplastic stiff person syndrome," JAMA Neurology, vol.
(ODC), the rate-limiting enzyme of polyamine biosynthesis, plays an important role in polyamine generation, whereas spermidine/spermine[N.sup.1]-acetyltransferase (SSAT) is the rate-limiting enzyme of catabolism (Figure 1).
Gene encoding histidine decarboxylase
(HDC) was amplified from the above said genomic DNA using HDC specific primers [JV16 HD 5'-AGATGGTATTGTTTCTTATG-3' and JV17 HD 5'-AGACCATACACCATAACCTT-3'], as described by (Jeune et al, 1995).
Although there is increasing evidence for the relationship between epilepsy and high levels of glutamic acid decarboxylase
antibody (GADA), the clinical significance is still uncertain (4,5).
The biochemical tests showed positive results for O-nitrophenyl- b-D-galactopyranoside, arginine dehydrolyase, lysine decarboxylase
, citrate utilization, indole production, gelatinase and Voges Proskauer.
Emma Styles, 22, came up with her idea for the latest social media challenge after Luke was diagnosed with aromatic l-amino acid decarboxylase
The five PLP-dependent enzymes--glutamate decarboxylase
, arginine decarboxylase
, histamine decarboxylase
, aromatic L-amino acid decarboxylase
, and sulfoalanine decarboxylase
are unrivaled in the variety of reactions they catalyze." Carbidopa may induce life-threatening events, including myocardial infarction, neuroleptic malignant syndrome, agranulocytosis, hemolytic and nonhemolytic anemia, gastrointestinal bleeding, thrombocytopenia, hypokalemia, and 90 other syndromes.
At disease onset, most type 1 diabetes patients have autoantibodies to 1 or more of the following: islet cell cytoplasm, insulin [insulin autoantibodies (IAAs)],  the 65-kDa isoform of glutamic acid decarboxylase
(GAD65), insulinoma-associated antigen 2 (IA-2), and zinc transporter 8 (ZnT8) (these are collectively termed islet autoantibodies).
The production of the 1-hydroxy-1-phenyl-2-propanoneis carried out by pyruvate decarboxylase
(PDC) and is accompanied with the formation of by-productsi.e.
Zinc (Zn) acts as a co-factor of glutamic acid decarboxylase
, an enzyme which maintains the production of GABA in central nervous system and decreased level of Zn in CSF has also been observed in febrile seizures.