of cytotoxic T cells
, as compared to the vaccination with the antigen alone.
Cytotoxic T cells
are a subpopulation of white blood cells that have an essential role in fighting viral infections.
One of the reasons for the lower incidence of GVHD may be the reduced cytotoxic potential of cord blood (CB)-derived natural killer (NK) and cytotoxic T cells
, as well as reduced levels of T helper I (Thl) cytokines, which are known to take part in the GVHD mechanistic cascade (7-10).
Galenica's GPI-0100 series are safe semi-synthetic derivatives from certain natural saponins which have the capability of stimulating Th 1 immunity with production of antigen-specific cytotoxic T cells
(CTL) that will seek out and destroy cells carrying abnormal markers such as viral or tumor antigens.
The immune system uses natural killer (NK) and cytotoxic T cells
to help eliminate viral infections and cancer cells, explains Christoph Wuelfing, assistant professor in the Center for Immunology.