The first step is meticulous examination of peripheral blood count values to make the initial crucial distinction between single cytopenia
such as anaemia, low white count or reduced platelets, in contrast to pancytopenia in which all the levels are subnormal or pancytopenia is a problem.
6,7) The cytopenias
may develop before the diagnosis of Sjogren's syndrome, and sicca symptoms may not be the predominant manifestation.
In conclusion, although the criteria of familial HLH were not appropriate for IAHS, in patients with infection and progression of hepatosplenomegaly and cytopenia
, the diagnosis of IAHS should be kept in mind.
The MDS are clonal disorders of haematopoietic stem cells characterized by ineffective haematopoiesis leading to blood cytopenias
and by high incidence of progression to acute myeloid leukemia (AML) (18).
5[degrees]C Present Present ([dagger]) Cytopenia
, 2 of 3 lineages ANC, cells/[mm.
The diagnosis of myelodysplastic syndrome (MDS) is based on morphologic criteria, which require cytopenia
accompanied by dysplasia in more than 10% of nucleated bone marrow (BM) cells.
Delayed-onset peripheral blood cytopenia
after rituximab: frequency and risk factor assessment in a consecutive series of 77 treatments.
([greater than Present Present or equal to] 2/3 lineages) Anaemia (Hb [less than or 8.
ALL, Philadelphia chromosome-positive acute lymphoblastic leukemia; MDS, myelodysplastic syndrome; SAA, severe aplastic anemia; AML, acute myeloid leukemia; CR2, second CR; RCMD, refractory cytopenia
with multilineage dysplasia; TD, transfusion dependent; RL1, first relapse; BMT, BM transplantation; RAEB, refractory anemia with excessive blast; RPB, related PB; CB, cord blood; M, myeloablative; CMV, cytomegalovirus; GvHD, graft vs host disease.
24-29 Colonoscopy examination is usually contraindicated due to risks associated with cytopenia
, bleeding, and the potential risk of gut perforation.
These adverse effects include nausea/vomiting, diarrhea, constipation, pain, infections, cytopenia
, allergic reactions, mucositis, osteoporosis, and neuropathy.
In dogs and cats, neutropenia is the most common cytopenia
associated with chemotherapy-induced myelosuppression.
HLH is a severe inflammatory and aggressive condition, characterized by high fever, hepatosplenomegaly, lymphadenopathy and cytopenia
Common drugs associated with blood dyscrasias Aplasia Agranulocytosis Thrombo- Haemolytic cytopenia
anaemia Gold Anti-thyroid Gold Beta-lactams drugs Choramphenicol Phenylbutazone Heparin Quinine/ quinidine Penicillamine Sulphonamide Quinine/ Thiazides quinidine NSAIDs Clozapine Sulphonamides Sulphonamides Sulphonamides Phenothiazines Anticonvulsants NSAIDs Anti-thyroid Mianserin NSAIDs Rifampicin drugs Sulphonylureas NSAIDs Diuretics Isoniazid Phenothiazides Beta-lactams Rifampicin Phenothiazines Allopurinol Captopril Sulphonylureas Sulphonylureas [H.
The hematologic presentation of CMML is heterogeneous, ranging from isolated monocytosis without cytopenia
, as seen in this patient, to a frank myeloproliferative disorder with leukocytosis and splenomegaly, similar to chronic myeloid leukemia (CML).