Astex was the first group in the world to successfully determine the 3-dimensional crystal structure of a human cytochrome
P450 enzyme and has a number of granted patent in the UK, Europe and in the United States including:
This article examines alcohol metabolism in the liver by the enzyme cytochrome
P450 2E1 (CYP2E1) and the role of this enzyme in creating a harmful condition known as oxidative stress.
Doxorubicin treatment in vivo causes cytochrome
c releae and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency superoxide dismutase activity and Bcl-2: Bax Ratio 1.
P450 2D6 is one of the isoforms of the cytochrome
P450 enzyme family.
25), and the cytochrome
b gene was amplified and sequenced as described previously for cotton rat identification (22,26).
c oxidase, the terminal oxidase in the respiratory chain, reduces oxygen to water through electron and proton transfer.
Our discovery of the third member of this family of cytochrome
P450s gives us an exclusive advantage to develop CYP26 specific and pan inhibitors for a wide range of potential applications", stated Dr.
Resolution of this dilemma is apparent in the finding of a mitochondrial soluble reduced cytochrome
c peroxidase (CCP) in H.
The impact of this macromolecular crowding on the electrochemical behavior of native cytochrome
c and a macromolecule-induced partially folded form of cytochrome
c has been studied using cyclic voltammetry.
The work builds on one of the human liver's principal drug-metabolizing enzymes, cytochrome
Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and Q-T prolongation have been reported in patients taking cisapride with other drugs that inhibit the cytochrome
P450-3A4 hepatic enzyme.
Cyterix is developing novel cancer therapeutics based on a prodrug approach that targets extra-hepatic cytochrome
P450 enzymes that are over-expressed in many cancers to a high frequency, but not in normal tissues.
After PB treatment, the activities of cytochrome
p-450 (CP), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphatamine demethylase (BD), aminopyrine demethylase (APD) and N.
The in vitro induction potential of the extracts was tested in freshly isolated human hepatocytes from 3 donors as influence on the catalytic activity of five cytochrome
P450 isoenzymes, namely 1A2, 2B6, 2C9, 2E1, and 3A4 on the respective marker substrates.
KEY WORDS: Abuse, and dependence; alcoholic liver disease; alcoholic fatty liver; ethanol metabolism; ethanol metabolite; cultured cells; recombinant cell lines; hepatocyte; alcohol dehydrogenase (ADH); acetaldehyde; cytochrome