cytidine


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Related to cytidine: Cytidine deaminase
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  • noun

Synonyms for cytidine

a nucleoside component of DNA

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An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.
NCC was selected from a series of 4-N-alkyl-substituted fluoronucleosides, which have been synthesized in order to address the toxicity issue of the parent compound FNC (2'-deoxy-2'-[beta]-fluoro-4'-azido-[beta]-D-arabinofuranosyl cytidine), (38 ) and after in vivo evaluation, NCC exhibited a significantly improved toxicity profile in mice.
Cas9 has also been fused end-to-end with cytidine deaminase [51] and adenine deaminase [52] (Figure 2(a)) in order to develop nucleotide base editors.
Decitabine is a pyrimidine analogue of the nucleoside cytidine [1].
The investigators modified the Cas9 by deactivating the RuvC catalytic domain and fusing it with two other enzymes: (1) Cytidine deaminase enzyme, which catalyzes the conversion of cytosine (C) to uracil (U) and (2) Uracil glycosylase inhibitor, which blocks the reversion of the U back to C.
Wingate et al., "Folding and hydrodynamics of a DNA i-motif from the c-MYC promoter determined by fluorescent cytidine analogs," Biophysical Journal, vol.
published an interesting observation of the loss of activation-induced cytidine deaminase (AID) in GCNIS and GCTs compared to the normal spermatocytes [49].
The drug classes included nucleosides analogues including adenosine analogues (Adefovir and Tenofovir), guanosine analogues (Entecavir and Ribavirin), cytidine analogue (Lamivudine), immunostimulant (Cycloferon), and Interferon-like analogues (Interferon, Pegylated Interferon alpha-2a).
A possible mechanism could be the presence of defects in the E2A-encoded transcription factor E47, responsible for defining the antibody diversity and downregulating AID (activation-induced cytidine deaminase) and CSR (class switch recombination) in the B cells of aged people [58].
Other miRs expressed in B cells such as miR-155 and miR-181b downregulate the activation-induced cytidine deaminase (AID) [171-173] which plays important role in the regulation of B cell activity.
First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy.
Robbiani et al (2015) studied malaria infections in mice and discovered that during prolonged immune responses to malaria, B lymphocytes multiply extensively and show prolonged expression of an enzyme called AID (activation-induced cytidine deaminase).
pylori cagA-positive strains induces aberrant expression of activation-induced cytidine deaminase (AID), a DNA editing enzyme that physiologically introduces somatic hypermutation in immunoglobulin variable regions in B cells.
Mechanisms include RNA interference pathways (29, 30), nonsense mediated decay via up-frame shift 1 (UPF1) (31), and antiviral proteins like apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) cytidine deaminase (32), Moloney leukemia virus 10 (MOV10) (33, 34), and zinc-finger antiviral protein (ZAP) (35, 36).
They are synthetised via the cytidine diphosphate (CDP) pathway which requires choline and consists of three enzymatic steps [47].