cyclooxygenase-2


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Synonyms for cyclooxygenase-2

an enzyme that makes prostaglandins that cause inflammation and pain and fever

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Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival.
Galer, M.D., and his colleagues demonstrated that pain relief from a 5% lidocaine patch was roughly equivalent to that from the cyclooxygenase-2 (COX-2) inhibitor, celecoxib (Celebrex), according to the findings of their randomized, controlled study.
Immunohistochemical staining for cyclooxygenase-2 and cluster of differentiation 95was performed on tissue microarray using standard procedures.
Cyclooxygenase is expressed in cells in three distinct isoforms, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cyclooxygenase-3 (COX-3) [13].
OBJECTIVES: We evaluated cyclooxygenase-2 (COX-2) expression and the signaling pathway leading to this induction due to Cr(VI) exposure in cultured cells.
The rationale for this treatment was that cyclooxygenase-2 has been shown to be a potential mechanism for the treatment of hepatocellular carcinoma (Wu 2006) and Hep3B liver cancer cell were reported to express at high level cyclooxygenase-2 messenger RNA, with the production of the relative cyclooxygenase-2 protein (Cheng et al.
Classes of drugs examined include SERMs and SERDs, aromatase inhibitors, microtubule binding agents, HER family inhibitors, angiogenesis inhibitors, miotic inhibitors, vaccines and immunomodulators, cyclooxygenase-2 inhibitors, and inhibitors of heat-shock proteins 90 and 27.
The most widely used NSAIDs were ibuprofen (Advil, Motrin), used by 44.5%: diclofenac (Voltaren), used by 23%, the selective cyclooxygenase-2 inhibitors celecoxib (Celebrex) and rofecoxib (Vioxx), used by 13.9% each; and naproxen (Meve), used by 4.7% of patients within 30 days of their cardiac arrest Under the study's case-crossover design, patients" use or nonuse of NSAIDs within 30 days prior to cardiac arrest was compared with their use or nonuse during two control periods: 60-90 and 90-120 days prior to their cardiac event.
The guide, which is entitled "Escogiendo Medicamentos Para el Dolor por Osteoartritis" (Choosing Pain Medication for Osteoarthritis), summarizes the effectiveness, cost, and potential side effects of NSAIDs, cyclooxygenase-2 inhibitors, Tylenol, and other medications.
Cyclooxygenase-2 inhibitors are appropriate as a supplemental strategy in the prevention of colorectal cancer in patients at highest risk for the disease.
Cyclooxygenase-2 (COX-2) is an inducible isoform of COX, which is expressed in very limited fashion throughout most tissues unless induced by inflammatory stimuli or mitogens.
CHICAGO -- Recent events surrounding selective cyclooxygenase-2 inhibitors will have far-reaching implications for future drug trials, Gary S.
UNITED KINGDOM -- Many health care workers have raised concerns about the use of cyclooxygenase-2 (COX)-2 inhibitors and their relationship to a higher risk of adverse cardiovascular events, but not much is known about the risks associated with other nonsteroidal anti-inflammatory drugs (NSAIDs).
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