in cancer: progress and perspective.
Their proteomic approach revealed elevated expression of cyclooxygenase
during the early stages of experimental UTI in mouse urinary bladders.
Westover, "Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase
2, and fever," Clinical Infectious Diseases, vol.
Cyclooxygenase-independent Actions of Cyclooxygenase
Chan, A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase
inhibitors, Journal of Inflammation Research, 45(2), 68-74 (1996).
Kargman et al., "Suppression of intestinal polyposis in ApcA716 knockout mice by inhibition of cyclooxygenase
2 (COX-2)," Cell, vol.
We have assessed the benefit of a virtual screening of alpha-Patchouli alcohol isomer (CID521903, CID442384, and/or CID6432585) as inhibitors of cyclooxygenase
(COX-1/COX-2) isoenzymes, only with interaction energy by hydrogen binding by LeadIT Biosolve software .
Of late the consensus is that at least part of the mechanism is inhibition of cyclooxygenase
(COX), in particular COX-2.
PGE2 regulates and modulates renal hemodynamics and tubular water and salt transport.[sup.7] Cyclooxygenase
(COX) is the major rate-limiting enzyme in the cascade leading to synthesis of PG from arachidonic acid.
The expression of cyclooxygenase
in transitional cell carcinoma cell lines: its correlation with tumor differentiation, invasiveness and prostanoids production.
Omega-3 fatty acids inhibit an enzyme called cyclooxygenase
and reduce the synthesis of arachidonic acid, both of which are associated with inflammation in the body.
In animal models, the cyclooxygenase
2 inhibitor celecoxib, better known by its brand name Celebrex, inhibits the development of ultraviolet-induced pre-malignant skin papillomas, which are thought to correspond to actinic keratoses, the pre-malignant precursor of non-melanoma skin cancers
Finally in order to evaluate the role of endothelium, nitric oxide (NO) and cyclooxygenase
products in producing this action, scientists formed three sub groups of rings, one of which was endothelium deprived.