Provoked coronary spasm
is defined as a reduction of >50% in the luminal diameter accompanied by symptoms and/or ischemic ST-segment changes from the evaluation after the administration of nitroglycerin (Kusama et al 2011).
Characteristics of coronary spasm
in patients presented as suspected ST-elevation myocardial infarction
Despite being on high doses of intravenous infusions of Adrenaline and Dopamine, coronary spasm
in all three coronary vessels was relieved with 100 mcg of intracoronary nitroglycerin suggesting that local release of nitric oxide in the epicardial vessels can negate the effects of systemically administered vasoconstricting agents.
6) carried out a retrospective analysis of 325 patients presenting with coronary spasm
between 1994 and 2000 in Korea.
A missense GIu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm
in the Japanese.
pentaphyllum leaves and of the pure gypenosides III and VIII produced a protective effect against vasopressin-induced coronary spasm
, arrhythmias and pressor response and a protective and suppressive effect on ouabain-induced arrhythmias in the anaesthetized guinea-pigs.
Other adverse effects associated with the use of ephedrine include palpitations, tachycardia, hypertension, coronary spasm
, paranoid psychoses, convulsions, respiratory depression, coma, and death (2).
Recent research suggests that coronary spasm
, such as that apparently caused by Imitrex, can gradually damage heart vessels over the long term.
7 times the risk of coronary spasm
faced by nonsmoking women.
The decades of the 1970s and 1980s saw the development of the Beta -blockers, calcium blockers, and thrombolytics; the identification of the major epidemiological risk factors; the performance of coronary bypass operations and angioplasty; and the role of coronary spasm
and dynamic coronary obstruction.
Sympathetic hyperactivity in hypertensive patients also promotes the onset of ACS, coronary spasm
, and coronary thrombosis.
The FFR-related complications included coronary spasm
, dissection, perforation and intra-stent thrombosis.
It is now accepted that in a substantial number of cases sudden death may result from coronary spasm
or cardiac arrhythmia or resulting from blockade or pathology in electrophysiological pathway of heart in the absence of any gross or histopathological changes in heart.
Guidelines recommend not to use beta-adrenergic receptor blockers for patients with an AMI caused by cocaine, because of risk of exacerbating coronary spasm