However no effect on general behaviour, inclined plane test, rota rod performance, thiopental induced sleep and
conditioned avoidance response.
The plant extract was further evaluated for nootropic activity using conditioned avoidance response in rats.
The nootropic activity of Carum carvi was evaluated by using the conditioned avoidance response (CAR) in rats as described by Cook & Weidley (1957).
Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit
conditioned avoidance response in rats.
For instance, four decades ago Costello (1970) argued that the types of
conditioned avoidance responses that have been regarded by behavior therapists as providing adequate experimental analogs of phobic behavior are dissimilar to such behaviors because (a) avoidance responses can be viewed as adequate coping behaviors, and (b) they do not involve conflict with approach behaviors, and such a conflict appears to be characteristic of clinical phobias.