In their study, the concordance rates
were better in all 3 preparation types in the positive reference diagnoses compared with the negative reference diagnoses.
The improvement in positive concordance rate
after 2008 may be due to several factors, including the experience gained over the years in performing HER2 testing, increasing the IA threshold for 3+ scoring, and more importantly, measures taken by the laboratory to be compliant with ASCO/CAP recommendations.
In summary, cytotechnologists had significantly higher concordance rates
for non-small cell carcinoma and adenocarcinoma, while pathologists performed better for carcinoid tumor (Table 3).
The concordance rates
for the HER2 IHC positive and negative cases are similar to the 2008 survey data, although again the comparison is limited because of a low response rate (161 out of 224 participants).
In our study, concordance rates
for adeno-carcinoma and SCC were 54.
for Target Diagnoses of Low-Grade Squamous Intraepithelial Lesion (LSIL), High-Grade Squamous Intraepithelial Lesion (HSIL), and Squamous Cell Carcinoma (SCC) by Year Target Diagnosis 2006 2007 LSIL concordance rate
, 967 (79.
In tumors with an equivocal EGFR immunohistochemistry score according to the reference evaluation, the mean concordance rate
The figure plots the annual concordance rates
by reader type and demonstrates improved concordance over time for cytotechnologists; pathologist performance has remained relatively unchanged.
For instance, in a study looking at use of WSI for subspecialty consultation, Wilbur and colleagues (14) at Massachusetts General Hospital reported an overall concordance rate
between WSI and glass slide interpretations of 91%, based on review of 53 consultation-level cases.
Using this method, Williams et al (10) found a grade concordance rate
To assess the concordance rate
between the results of manual HER2/neu IHC score and automated HER2/neu IHC image analysis interpretation for gastroesophageal adenocarcinoma biopsy and resection specimens, we compared the positive, intermediate, and negative results for each examination.
Our study showed that the concordance rate
between the cytologic and histologic diagnoses distinguishing SCLC from NSCLC by different pathologists in our practice is high.
Participant Concordance Rate
for Gastrointestinal Cytology Challenges by Slide Preparation Type and the General Category of Positive/ Malignant and Suspicious Conventional Cytospin ThinPrep No.
When the classic preparation results were broken down further into either cytospin or concentrated smear, the concordance rate
remained the same at 92% for both.
2) Positive minimum n = 228 n = 427 concordance rate
<90% 31 (13.