References in periodicals archive ?
Table 19: Incidence of EPS Compared to Placebo in the Adjunctive Therapy Bipolar Depression Studies LATUDA Placebo 20to 120 mg/day (N=334) (N=360) Adverse Event Term (%) (%) All EPS events 13 24 All EPS events, excluding 9 14 Akathisia/ Restlessness Akathisia 5 11 Dystonia * <1 1 Parkinsonism ** 8 13 Restlessness <1 4 Note: Figures rounded to the nearest integer * Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus ** Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor
Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA Adverse Event Term Placebo 20 to 60 mg/day 80 to 120 mg/day (N=168) (N=164) (N=167) (%) (%) (%) All EPS events 5 12 20 All EPS events, 2 5 9 excluding Akathisia/ Restlessness Akathisia 2 8 11 Dystonia* 0 0 2 Parkinsonism** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer *Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus **Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor
Many, many summers before I went up to Mt Rigi in a cogwheel, Mark Twain had undertaken the same journey and it had made an impact enough on him to have remarked, "This is the charmingest place we have ever lived in for repose and restfulness".
At this point, he had minimal respiratory effort and cogwheel rigidity, but was able to communicate with us to a limited degree by squeezing our hands.
At the 1-month neurobehavioral assessment, completed on the 27th day of life during a home visit, the infant displayed the following clinical signs or symptoms: hypertonicity in the trunk and upper and lower extremities, setting sun sign, tremors, cogwheel movements and athetoid finger posturing, high-pitch cry, and extreme irritability (Table 3).
In order to eliminate the main shortcomings of radial harmonic transmissions currently being manufactured--shortcomings mainly due to the constructive shape of the flexible cogwheel and the type of alternating-symmetrical bending stress occurring in the body of the flexible wheel and of the special ball bearing--there have been new variants developed, that can diminish and even eliminate these disadvantages.
US recognition depends on the finding of a normal ovary with intact blood flow beside a fluid-filled, thin-walled, tender, cystic structure with some of the previously mentioned sonomarkers of tubal occlusion such as the bead-on-a-string or cogwheel sign (FIGURE 50-5G).
10) Cogwheel rigidity is a "jerky" movement experienced in response to passive motion that reflects alterations in muscle tension and relaxation.
Combining a cogwheel, rack and pinion, and fixed chains, the platform enables good approach accuracy and guide precision.
Kneeling near her left hand is a man holding a cogwheel representing manufacturing.
Its engineers developed a cogwheel made from two plastics that together achieved optimum friction and wear characteristics.
In terms of getting there, most people take a cogwheel train straight up the mountain.
A 78-year-old woman with idiopathic Parkinson disease diagnosed one year before had mild cogwheel rigidity worse on the left side and intermittent pill-rolling tremors mainly in the left hand.
At interview he demonstrated severe bradykinesia, stiffness to the point of suppression of normal lithium tremor, and cogwheel rigidity; oral-buccal dystonia caused speech to be slow and labored.