Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA Adverse Event Term Placebo 20 to 60 mg/day 80 to 120 mg/day (N=168) (N=164) (N=167) (%) (%) (%) All EPS events 5 12 20 All EPS events, 2 5 9 excluding Akathisia/ Restlessness Akathisia 2 8 11 Dystonia* 0 0 2 Parkinsonism** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer *Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus **Parkinsonism includes adverse event terms: bradykinesia, cogwheel
rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor
At low velocity values, the tensile strength fluctuations can be evidently ascribed to experimental artifacts likely due to cogwheel
characteristic frequency, and the signal seems stationary, whereas at higher velocities a sustained oscillation sets in.
The old train station is much grander than one might expect for a town at the end of a spur not used since the Sixties, when the Viet Cong severed the cogwheel
link to the main line.
Many, many summers before I went up to Mt Rigi in a cogwheel
, Mark Twain had undertaken the same journey and it had made an impact enough on him to have remarked, "This is the charmingest place we have ever lived in for repose and restfulness".
Increasing demand for new technology products and changing lifestyles tilting towards greater dependence on modern technology are the real stimulants that will keep the cogwheel
of the electronics market moving.
At this point, he had minimal respiratory effort and cogwheel
rigidity, but was able to communicate with us to a limited degree by squeezing our hands.
A bizarre but enjoyably sociable experience, we climbed aboard the world's oldest electric cogwheel
train, which slowly climbed the snowy mountain while we enjoyed wine and pretzels.
At the 1-month neurobehavioral assessment, completed on the 27th day of life during a home visit, the infant displayed the following clinical signs or symptoms: hypertonicity in the trunk and upper and lower extremities, setting sun sign, tremors, cogwheel
movements and athetoid finger posturing, high-pitch cry, and extreme irritability (Table 3).
In order to eliminate the main shortcomings of radial harmonic transmissions currently being manufactured--shortcomings mainly due to the constructive shape of the flexible cogwheel
and the type of alternating-symmetrical bending stress occurring in the body of the flexible wheel and of the special ball bearing--there have been new variants developed, that can diminish and even eliminate these disadvantages.
Along wTith its numerous outlying slave labor camps it was initially intended, according to Polish scholar Janina Grabowsky, as "a camp of political terror against Poles," In the course of time, however, "it became a major cogwheel
in the German machinery of destruction against the people of Europe, at the end--and above all--against the Jews.
In CSA related to central degenerative disorder, concomitant symptoms of the underlying disorder may be present; these may include ataxia, dementia, cogwheel
rigidity or dysautonomia.
Summer and winter, thousands of visitors from around the globe make the trip on Europe''s highest cogwheel
railway, via the Kleine Scheidegg plateau, on a looping run through the Eiger and Monch mountains to the 'Top of Europe'' station.
rigidity is a "jerky" movement experienced in response to passive motion that reflects alterations in muscle tension and relaxation.
RAIL TOUR OF SWISS ALPS: Switzerland Travel Centre (0207 420 4900) offers two-night break, on deps to Jan 31 for pounds 418, with flights ex-Heathrow, rail transfers, three-star hotel B&B and excursions including cogwheel
train to summit of Mount Rigi.
Kneeling near her left hand is a man holding a cogwheel