She had been prescribed Clozapine
to control the side effects caused by brain damage.
The algorithm recommends electroconvulsive therapy if there is inadequate response to clozapine
alone or with fluvoxamine, which sometimes is used to boost clozapine
serum level, especially in patients who are heavy smokers.
After a series of hospitalizations in her 20s and 30s, clozapine
was initiated and she has not required additional inpatient psychiatric care.
Patients directly purchased clozapine
from Novartis Venezuela.
Key words: clozapine
, schizophrenia, malignant syndrome, withdrawal reaction
Unfortunately, consistent with her medical history she was not very responsive to the new treatment; therefore, we decided to reinitiate clozapine
The efficacy and safety of extremely low doses of clozapine
in the treatment of psychosis in PD patients were confirmed in two double-blind, placebo-controlled clinical trials [25, 26].
3) Reports from Europe in the 1970s described an incidence of agranulocytosis among patients given clozapine
of 1% to 2% per year, and mortality among agranulocytosis cases of 32%.
The company added that the US Food and Drug Administration (FDA) has approved Clozapine
Orally Disintegrating Tablets, 25 mg and 100 mg for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment.
is the best treatment for TRS patients, the aim of the present study is to investigate wether clozapine
is actually and adequately prescribed for patients with TRS as well as to evaluate the patterns of antipsychotic drugs prescription for patients with TRS in the CAPS of Sao Paulo.
is a medication that was banned after several deaths of people taking it in the 1960s.
Mice were randomly divided into four groups as follows: Saline-saline group, saline- clozapine
, MK-801-saline group.
is an atypical antipsychotic drug that has been commercially marketed since 1990.
The first known drug from this group is clozapine
has shown to have superior efficacy compared to other antipsychotics and is the drug of choice for treatment -resistant schizophrenia.