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capable of being cleaved

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References in periodicals archive ?
Cleavable linkers may increase the possibility of bystander effect (27).
RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers.
All virulent strains have multiple basic amino acid residues at positions 112-116 and a phenyl alanine at position 117, making them cleavable by most of the ubiquitously distributed intracellular furin-like proteases in various chicken tissues [26].
Wang and coworkers also developed a redox and pH dual-responsive nanocarrier for site-specific drug delivery, in which poly(acrylic acid) (PAA) was grafted in the outlets of PNS through cleavable disulfide bonds.
developed MORAb-202, which combines anticancer agent farletuzumab, an IgG1 monoclonal antibody that binds to the folate receptor alpha, and Eisai's in-house developed anticancer agent eribulin using an enzyme cleavable linker.
MEN1309/OBT076 is a fully humanized IgG1 monoclonal antibody conjugated to a potent cytotoxic maytansinoid toxin via a cleavable linker.
This vector permits the genes of interest to be fused to the thioredoxin fusion protein, trxA, for high levels of expression with good solubility and it also contains cleavable His-tag sequences for detection and purification.
Dai, "Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing," Journal of the American Chemical Society, vol.
This cleavable peptide linker between PEG layer and the remainder of the NP represents a unique method of tumor targeting (Figure 6) [135].
(2004), who assert that the histidine residue in the highly conserved active site RHGXRXP- serves as a nucleophile in the formation of a covalent phosphohistidine intermediate, while the aspartic acid residue from the C-terminal in the conserved sequence HD serves as a proton donor to the oxygen atom of the cleavable phosphomonoester bond, generating myo-inositol monophosphate as the final product.
PA polypeptide chain has the cleavable N-terminal leader peptide targeting the protein to the secretion via Sec pathway.
Hellberg, Ortho Ester-Based Cleavable Cationic Surfactants, J.
(1995) Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells.
Liu, "Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin," Cancer Research, vol.
Tom20 and Tom22 mainly recognize the presequences of cleavable precursor proteins, while Tom70 typically largely recognizes the internal targeting signals of hydrophobic precursor proteins, many of which are inner membrane metabolite carriers [58].