Albumin-bound toxins move between the plasma, albumin molecules bound to the albumin dialysate side of the MARSFLUX and the circulating albumin
solution (Fealy et al., 2005).
Aldoxorubicin combines doxorubicin with an innovative single-molecule linker that binds directly and specifically to circulating albumin
, the most abundant protein in the bloodstream.
In the majority of cases, the disorder is detected by electrophoretic screening of plasma proteins, which shows either the complete absence of or the presence of very low amounts of circulating albumin
(1) ranging from 0.01 to 1000 mg/L (2, 3).
Exposure to ischemic myocardium modifies circulating albumin
at its NHZ terminus by different mechanisms, and this modification is the basis of IMA measurement by the albumin cobalt binding (ACB) test (3).
All four presented with low circulating albumin
, but the values were >1 g/L, which is conventionally accepted as indicative of analbuminemia.