A study carried out at the University of Eastern Finland and published in Nucleic Acids Research investigated the effect of ciprofloxacin on mitochondria, the important cell organelles in our body that produce the energy for cellular function.
Such an approach is being taken by the British Association for Sexual Health and HIV, who announced revised treatment guidelines to recommend treating with ciprofloxacin if susceptibility results are available prior to treatment.
Researchers developed a real-time reverse transcription polymerase chain reaction test for a mutation of codon 91 in the gyrase A (gyrA)gene in N.gonorrhoeae that reliably predicts resistance to ciprofloxacin.
(10) The use of ciprofloxacin 500 mg orally as an alternative to a 250 mg ceftriaxone injection for the treatment of Neisseria gonorrhoeae infections has been made possible by the development of a rapid genotypic assay for the determination of mutation at codon 91 of the gyrase A (gyrA) gene of Neisseria gonorrhoeae; a non-mutated (wild-type) gyrA genotype reliably predicts full susceptibility to ciprofloxacin.
CHICAGO -- An investigational antibiotic was just as effective as ciprofloxacin at curing travelers' diarrhea but was associated with a significantly lower rate of colonization with extended spectrum beta-lactam-resistant Escherichia coli, a phase III trial has determined.