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Related to chylomicronemia syndrome: familial chylomicronemia syndrome
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The product is intended for the treatment of patients with Familial Chylomicronemia Syndrome.
Very severe triglyceride elevations (greater than 2,000 mg/dL) increase the risk of pancreatitis in the chylomicronemia syndrome.
i) Familial Chylomicronemia Syndrome with either Lipoprotein Lipase (LPL) Deficiency or Apolipoprotein C II deficiency or
Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome.
Drugs currently in Phase 3 development include volanesorsen, a drug Ionis is developing and plans to commercialize through its wholly owned subsidiary, Akcea Therapeutics, to treat patients with either familial chylomicronemia syndrome or familial partial lipodystrophy; and IONIS-TTRRx, a drug Ionis is developing with GSK to treat patients with TTR amyloidosis.