4-6) It was suggested that the lack of anti-inflammatory cytokines such as IL-4 and IL-10 may contribute to the initiation and progression of inflammation during chronic synovitis
in RA joints.
Sometimes there is damage to the surface of the joint that does not show up on any tests, such as an X-ray or MRI, even though it continues to cause irritation and excess fluid.
Dysfunctional inflammatory cells in inflammation region Accumulation of inflammatory mediators Chronic synovitis
Continuation of antigenic stimulus?
We present the case of a 68-year-old woman with chronic synovitis
showing multiple plasma cells containing PAS-positive Dutcher bodies and no evidence of a lymphoproliferative disorder.
In a case series of the synovial joint complications of SED, Sambrook et al noted cases of chronic synovitis
and radiologically evident chondrocalcinosis in multiple joints.