It was found that Notch1 expression and nuclear translocation was absent in all of the 10 noncancerous endoscopic gastric mucosa specimens and became detectable in 20.8% (5 of 24) and 16.7% (4 of 24) of chronic gastritis
and in 61.1% (11 of 18) and 50.0% (9 of 18) of IMs, respectively.
pylori-related chronic gastritis
has been inconclusive, even in Thailand.
Marshall, "Unidentified curved bacilli on gastric epithelium in active chronic gastritis
," The Lancet, vol.
In this study, we used the Sydney system grading of chronic gastritis
for grading of chronicity, activity, and H.
Figure 2 depicts acute on chronic gastritis
. Gastric ulcer was diagnosed in 7 (11.66%) cases, out of which 2 cases were associated with intestinal metaplasia.
pylori infection is related to gastric carcinoma, possibly inducing chronic gastritis
, and progresses to the premalignant stages of atrophic gastritis, intestinal metaplasia, and, eventually, gastric carcinoma [4-6].
The disorder was originally described by Colletti and Trainer (1) in a 15-year-old girl with refractory Helicobacter pylori-negative chronic gastritis
in which these specific histologic features were first noted.
Determinants of Helicobacter pylori infection and chronic gastritis
. The American Journal of Gastroenterology.1995; 90(7):1094-1101.
Taniguchi et al., "Distribution of inflammation and atrophy in the stomach of Helicobacter pylori-positive and -negative patients with chronic gastritis
," American Journal of Gastroenterology, vol.
Atrophy or intestinal metaplasia were present in 10% of biopsies diagnosed as H pylori-associated chronic gastritis
, although lymphoid follicles were present in most biopsies.
: The symptoms associated with chronic gastritis
are typically less severe but more persistent.
It has been closely linked with chronic gastritis
, peptic ulcer, gastric carcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma .
With respect to pathological diagnoses, 149, 67, 8, 25, and 0 lesions were diagnosed as chronic gastritis
, intestinal metaplasia, low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasia/early gastric cancer, and multiple types of cancer, respectively.
Similarly in this study UGI-scopy showed lax cardia and fundal gastritis in 7 (10.6%), chronic diffuse erosive gastritis in 1 (1.5%), lax cardia and grade b esophagitis in 5 (7.8%), scattered gastric erosions in fundus and antrum in 2 (3.0%), periampullary diverticulum in second part of duodenum in 1 (1.5%), lax cardia with fundal gastritis and grade a esophagitis in 3 (4.5%), diffuse chronic gastritis
in 2 (3.0%), lax cardia with bile reflux esophagitis and duodenitis in 1 (1.5%), lax cardia and hiatus hernia in 1 (1.5%), bile reflux gastritis in 1 (1.5%).
Malamut et al (14) found that chronic gastritis
with/without pernicious anemia in the gastric mucosa and microscopic colitis in the colonic mucosa were the most frequent histopathologic observations in the gastrointestinal tract in CVID patients.