It is believed that laser photocoagulation may not have adequate efficacy in cases of CNV secondary to choroidal osteoma due to insufficient tumor melanine and a thinned, degenerated RPE-Bruch's membrane complex.
5,6) It is thought that in choroidal osteoma cases, normal tissues are also damaged during the process, and VEGF expression is increased as a result of choroidal and retinal ischemic stress and chronic inflammation.
The first reported use of intravitreal ranibizumab injection for CNV secondary to choroidal osteoma was by Song and Roh (5) in 2009; they found that CNV had regressed and visual acuity had improved from 20/200 to 20/100 at 6 months post-injection.
In conclusion, although intravitreal ranibizumab injection is highly beneficial in the treatment of CNV secondary to choroidal osteoma in terms of visual acuity and anatomic recovery, recurrence may be observed, as our case also shows.
Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma.
Song M, Roh Y Intravitreal Ranibizumab in a patient with choroidal neovascularization secondary to choroidal osteoma.
Dramatic response of choroidal neovascularization associated with choroidal osteoma to the intravitreal injection of bevacizumab(Avastin).