The present study reveals the antiangiogenic potency of RA using human umbilical vein endothelial cell (HUVEC) (a classical in vitro cell model mimicking tumor vascular endothelial cells), chick chorioallantoic
membrane (CAM) model, and transgenic zebrafish angiogenesis model.
Chick embryo chorioallantoic
membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules.
membrane develops from two extraembryonic structures: the chorion and allantois.
a prototype that would inject vaccine into the chorioallantoic
Separately, MB Research Laboratories of Spinnerstown, Pennsylvania, conducted a non-animal ocular irritancy study using the Chorioallantoic
membrane alternative to the Draize method, a dermal irritancy study using the MatTek EpiDerm MTT viability assay, and an Acute Oral Toxicity test using the Up and Down procedure (UDP).
that first proposed the hypothesis, and subsequent reports by Chicago researchers in which cartilage fragments grafted onto chick embryo chorioallantoic
membrane resisted vascular invasion.
Those eggs that contained viable embryos with blood vessels in the chorioallantoic
membrane and visible heartbeats were then resealed with clear tape.
In another study, the Cramb group is investigating the development of a model system for TPE-PDT using the chorioallantoic
membrane (CAM) of the chick embryo.
placenta formation in the rat: angiogenesis and maternal blood circulation in the mesometrial region of the implantation chamber prior to placenta formation.
CGEN-25017, which was initially discovered using Compugen's Disease-Associated Conformation (DAC) Blockers discovery platform, had previously demonstrated significant inhibitory activity in two other models of angiogenesis, an in vitro multi-cellular assay and the widely recognized chorioallantoic
membrane (CAM) model.
For infection, fertilized chicken eggs at embryonation day 11 were inoculated with virus into the allantois sack or onto the chorioallantoic
1998), the chick embryo chorioallantoic
membrane model (Zhang et al.
Moreover, in an in vivo model of the chorioallantoic
membrane of the chicken embryo, prolactin enhances vessel density and the tortuosity of the vasculature and pillar formation, which are hallmarks of intussusceptive angiogenesis.
Avian influenza virus, Newcastle disease virus, and infectious bronchitis virus were eliminated as potential causative agents after pharyngeal swabs inoculated onto the chorioallantoic
membrane of embryonate eggs failed to recover viable virus.
Instead, the chorioallantoic
membrane, the major respiratory organ of the avian (Piiper et al.