Chondroblastoma and chondromyxoid fibroma
. J Am Acad Orthop Surg 2013; 21: 225-33.
Immunohistochemical analysis for Sox9 reveals the cartilaginous character of chondroblastoma and chondromyxoid fibroma
(CMF) is a slowly growing, benign bone tumor that is exceedingly rare within the temporal bone.
Differential diagnosis of the findings included benign fibrous lesions of bone-like non-ossifying fibroma and odontogenic fibroma, myxoma and chondromyxoid fibroma
or even fibrosarcoma.
In the differential diagnosis chondromyxoid fibroma
and osteitis fibrosa cystica were considered (Figs 1 a & b).
* The spectrum of these lesions includes enchondroma, osteochondroma, hemangioma, hemangiopericytoma, enostosis, osteoid osteoma, fibrous dysplasia, Paget disease, Langerhans cell histiocytosis, aneurysmal bone cyst, eosinophilic granuloma, giant cell tumor, brown tumor, nonossifying fibroma, and chondromyxoid fibroma
Others benign tumours were chondroma, osteochondroma, osteoma and chondromyxoid fibroma
. In malignant lesion, osteosarcoma and chondrosarcoma were common.
Review of the histology (figure 2, A) suggested a low-grade malignancy, and the diagnosis of a low-grade chondromyxoid neoplasm was made, with a differential diagnosis of chondromyxoid fibroma
, chondrosarcoma, and chondroblastic osteosarcoma.
Table 1: Malignant tumours Malignant tumours Frequency Percentage Dermatofibro sarcoma 1 1.4% Fibrosarcoma 5 7.1% Liposarcoma 1 1.4% Malignant firous histiocytoma 1 1.4% Osteosarcoma 8 11.4% Rhabdomyosarcoma 54 77.1% Total 70 100.0% Table 2: Benign tumours Benign tumours Frequency Percentage Angiofibroma 2 10.0% Chondroma 2 10.0% Chondromyxoid fibroma
1 5.0% Fibroma 1 5.0% Fibrous dysplasia 1 5.0% Fibrous histiocytoma 3 15.0% Giant cell tumours 2 10.0% Osteiod osteoma 2 10.0% Osteoblastoma 1 5.0% Osteochondroma 5 25.0% Total 20 100.0% Table 3: Anatomic location of the Tumours Location Frequency Percentage Arm 2 2.2% Axilla 5 5.6% Foot 5 5.6% Forearm 2 2.2% Groin 5 5.6% Hand 4 4.4% Head and neck 27 30.0% Leg 10 11.1% Thigh 10 11.1% Trunk 20 22.2% Total 90 100.0% Fig.
(15,18) Primary lesions most frequently associated with ABC (in order of frequency) include giant cell tumor of bone, chondroblastoma, chondromyxoid fibroma
, and fibrous dysplasia, particularly in pregnancy.
Fine needle aspiration cytology of chondroblastoma and chondromyxoid fibroma
. A report of two cases.