Also, blockade of cholinergic receptors
may aggravate AD symptoms, and prevent the increase in cholinergic transmission expected from increased acetylcholine in synapses as result of cholinesterase inhibition.
With the present work in developing sea urchins, chlorpyrifos elicited developmental anomalies similar to those seen previously for cholinergic receptor
agonists (55) such as nicotine (47).
Under normal physiologic conditions, the cholinergic receptors
are usually operative through Ach action, and atropine is known to occupy the cholinergic receptors
and interfere with the action of Ach (5,6).
About Asmacure Asmacure Ltee is a clinical-stage biopharmaceutical company focused on the development of novel, proprietary compounds that target cholinergic receptors
for the treatment of inflammation, notably pulmonary airway diseases.
In the study, 21 chronically ill Gulf War veterans and 17 healthy veterans were given small doses of physostigmine, a substance that briefly stimulates cholinergic receptors
Chapter topics include: the role of prefrontal cholinergic receptors
in the pathology of schizophrenia; participation of the prefrontal cortex in the processing of sexual and maternal incentives; the orbitofrontal cortex and emotional decision-making; the role of the prefrontal cortex in cognitive impairment in Parkison's disease, and noradrenergic actions in prefrontal cortex as they relate to AD/HD.
Asenapine binds to several serotonergic, dopaminergic, and a-adrenergic receptors, but has almost no affinity for muscarinic cholinergic receptors
, and so is assumed to cause fewer significant anticholinergic side effects, compared with other antipsychotic medications.
The phosphorylated AChE cannot break down ACh and accumulation of acetylcholine in the synaptic cleft causes excess stimulation at cholinergic receptors
throughout the central and peripheral nervous system.
Organophosphate pesticides cause decreased brain weight, decreased cholinergic receptors
, hyperactivity, motor and coordination problems in laboratory animals.
Muscarinic cholinergic receptors
in area postrema and brainstem areas regulating emesis.
Characterization of agonist and antagonist binding to muscarinic cholinergic receptors
solubilized from rat cerebral cortex.
2005) in mice indicated that the effect of escin is not abolished by anisodamine hydrobromide, which means that escin, similarly like [alpha]-hederin does not exert its effect on cholinergic receptors
Neurotoxic effects result when reactive oxon metabolites form covalent bonds with acetylcholinesterase (AChE) and inhibit AChE-catalyzed inactivation of the neurotransmitter acetylcholine, resulting in hyperstimulation of cholinergic receptors
and symptoms of acute OP toxicity.
Other genes of interest in schizophrenia include those that code for cholinergic receptors
, and others that code for proteins involved in oligodendrocyte growth.
Anticholinergics inhibit muscarinic cholinergic receptors