Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor
torcetrapib involve L-type calcium channels.
Cholesteryl ester transfer protein inhibitor
(JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia.
Torcetrapib, a potent cholesteryl ester transfer protein inhibitor
, markedly raised HDL-cholesterol levels, decreased LDL-cholesterol levels, and increased the particle size of both types of cholesterol in a pilot study, reported Margaret E.
Effect of the cholesteryl ester transfer protein inhibitor
, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies.
The ensuing chapters discuss apolipoprotein A-1 mutations, diversity of high-density lipoproteins, reverse cholesterol transport, ATP-binding cassette transporter A1 and G1, sphingolipids, lecithin and cholesterol acyltransferase, cholesteryl ester transfer protein inhibitors
, apoprotein mimetic peptides, oxidized HDL, paraoxonase-1, and use of proteomics techniques in HDL research.