The role of nuclear factor-kappa B in bacterial translocation in cholestatic
syndrome following pediatric liver transplantation and steroid-resistant graft rejection.
Primary biliary cirrhosis (PBC) is an idiopathic chronic inflammatory, cholestatic
, primarily T cell-mediated destruction of intra-hepatic microscopic bile ducts1.
On the other hand, the 2 sisters may have a different, and possibly more aggressive, familial cholestatic
However, recognizing that CMV is a hepatotropic agent, traditionally it is believed that this virus primarily affects the bile ducts with the development of cholestatic
hepatitis and a congenital abnormality of the bile duct [29,30].
Excessive ROS generated during cholestasis can cause oxidative damage to hepatocytes and the biliary tract, so consumption of antioxidants can have beneficial effects on cholestatic
The result of histological findings showed that there was insignificant presence of cholestatic
hepatitis in experimental groups as compared to control groups.
In hepatocellular diseases, features of liver injury, inflammation, and necrosis predominate while in cholestatic
diseases, features of inhibition of bile flow predominate.
The differential diagnosis for NP includes atopic dermatitis, contact dermatitis, drug eruptions, herpes zoster, idiopathic pruritus and systemic disease (such as renal, cholestatic
, or hematologic pruritus, or pruritus associated with malignancy), tinea corporis, tinea versicolor, and xerosis.
Biliary atresia is a neonatal cholestatic
disease characterized by progressive obliteration or discontinuity of the extrahepatic biliary system resulting in obstruction to bile flow.
As with many cholestatic
liver diseases, patients have hypercholesterolemia because of impaired cholesterol degradation.
Therefore, all babies with cholestatic
jaundice must be referred early for specialist evaluation and exclusion of biliary atresia.
Idiopathic adulthood ductopenia: a cause of chronic cholestatic
liver disease and biliary cirrhosis.
Cholestasis is the pivotal hallmark of the so-called chronic cholestatic
liver diseases (CCLDs), but it may also occur in the advanced stage of other chronic liver diseases (CLDs), such as alcoholic liver disease, nonalcoholic fatty liver disease, and chronic hepatitis B and chronic hepatitis C .
The occurrence of acute acalculous cholecystitis during the course of EBV infection is rare but reported, especially in those patients with cholestatic
hepatitis [5, 6].