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Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver: a case report.
Strobel, "CEUS in hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma in 320 patients--early or late washout matters: a subanalysis of the DEGUM multicenter trial," Ultraschall in der Medizin, vol.
Abbreviations AIC: Autoimmune cholangitis AIP: Autoimmune pancreatitis AIP1: Autoimmune pancreatitis type 1 AIP2: Autoimmune pancreatitis type 2 AP: Alkaline phosphatase CCC: Cholangiocellular carcinoma EUS: Endoscopic ultrasound-guided sonography GELs: Granulocytic epithelial lesions [gamma]-GT: [gamma]-Glutamyltransferase HCC: Hepatocellular carcinoma HLA: Human leukocyte antigen IBD: Inflammatory bowel disease IDCP: Idiopathic duct centric pancreatitis IgG4: Immunoglobulin G4 LPSP: Lymphoplasmacytic sclerosing pancreatitis MMF: Mycophenolate mofetil UC: Ulcerative colitis.
STIP1 was identified to be overexpressed in several kinds of cancers, such as colorectal carcinoma (CRC) [15], pancreatic cancer [16], cholangiocellular carcinoma (CCC) [17], ovarian cancer [18], and so on.
Hepatocellular carcinoma had a nonhomogeneous, sometimes chaotic, pattern of vascularization, and cholangiocellular carcinoma showed a nonhomogeneous parenchyma.
16 cases of isolated caudate lobectomy were performed for neoplasms confined to the caudate lobe, including seven cases of hepatocellular carcinoma (7/16, 43.75%), four cases of hepatic cavernous hemangioma (4/16, 25%), one case of hepatocellular adenoma (1/16, 6.25%), one case of inflammatory pseudotumor (1/16,6.25%), one case of hepatic hamartoma (1/16, 6.25%), one case of mixed hepatocellular carcinoma and cholangiocellular carcinoma (1/16, 6.25%), and one case of metastatic colonic cancer (1/16, 6.25%).
Dysplasia of the biliary epithelium generated by bile stasis and chronic inflammation can develop a malignant transformation to cholangiocellular carcinoma in 5% to 14% of patients with CD.